Hypoxamirs in pulmonary hypertension: breathing new life into pulmonary vascular research

Hypoxamirs in pulmonary hypertension: breathing new life into pulmonary vascular research

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Hypoxamirs in pulmonary hypertension: breathing new life into pulmonary vascular research

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Author Andrew E. Hale, Kevin White, Stephen Y. Chan

Abstract

In mammalian cells, hypoxia, or inadequate oxygen availability, regulates the expression of a specific set of microRNA, which we have previously termed “hypoxamirs”. Over the past five years, the appreciation of the importance of hypoxamirs in regulating the cellular adaptation to hypoxia has grown dramatically. At a cellular level, each hypoxamir can simultaneously regulate expression of multiple (>100) target genes in order to control fundamental biological processes, including survival, proliferation, angiogenesis, migration, and metabolism, among others. A maladaptive imbalance of these hypoxic phenotypes often drives many ischemic cardiovascular diseases, such as pulmonary hypertension—an enigmatic vascular disorder characterized by pronounced and severe panvasculopathy secondary to diverse upstream etiologies, notably including hypoxia. Yet, despite this pathogenic relationship between hypoxic cell phenotypes and disease, the mechanistic roles of hypoxamirs in modulating pulmonary hypertension remain largely unrecognized. Some advances have been made regarding the contributions of specific hypoxamirs in the development and progression of pulmonary hypertension. New methods are also being developed to more comprehensively study their roles in this complex disease. As a result, a more sophisticated understanding of their pervasive roles in pathogenesis could set the stage for unique diagnostic and therapeutic strategies in pulmonary hypertension.

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Posted by: Paul
Posted on: October 26, 2012 02:39 PM

The journal 'Cardiovascular Diagnosis and Therapy' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.

With strong international contribution on all levels, the goal of this new journal is to become a globally respected source of up-to-date information about all aspects of Cardiovascular Diagnosis and Therapy.

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