David T. Scadden, director of the Massachusetts General Hospital Center for Regenerative Medicine and an alumnus of the Case Western Reserve University School of Medicine, has been elected to membership in the prestigious Institute of Medicine (IOM), a group established by the National Academies of Science to analyze health issues and make recommendations on policy.
Scadden, whose work focuses on the regulation of normal and cancerous stem cells, serves as co-director of the department of developmental and regenerative biology at Harvard University and Harvard Medical School (HMS). He also co-directs the Harvard Stem Cell Institute and is Gerald and Darlene Jordan Professor of Medicine at HMS.
Following his internship and residency at the Brigham and Women's Hospital in Boston, Scadden completed a clinical fellowship in medicine and in hematology/oncology at Harvard Medical School, Brigham and Women's Hospital and the Dana-Farber Cancer Institute.
Scadden's research interests are focused on the bone marrow and stem cell biology. He is particularly interested in the regulation of entry and exit from the cell cycle, as this has important implications for expansion of stem cells and gene transduction. He is also interested in the regulation of stem cell localization to and within specific microenvironments and the interactions of stem cells with elements of the microenvironmental niche. These studies are critically important in understanding how stem cells develop and how they may function in regenerative processes in many organs. His work has been published in many outstanding journals including Nature, Nature Medicine, Science, Nature Biotechnology, Proceedings of the National Academy of Science USA, the Journal of Clinical Investigation, the Journal of Immunology and Blood. He has received many honors, including elected membership in the American Society for Clinical Investigation and the Association of American Physicians. He serves on the editorial boards for many journals including Blood, Stem Cells, and Experimental Hematology, and he is an associate editor for Blood.
Established in 1970, the IOM serves as a national resource for independent, scientifically informed analysis and recommendations on human health issues. Members commit to serve on IOM committees, which engage in a broad range of studies on health policy issues. Studies completed in the past year include Ending the Tobacco Problem: A Blueprint for the Nation and Nutrition Standards in Schools: Leading the Way Toward Healthier Youth. New members are elected by current active members and are selected based on professional achievement and commitment to service. Brown and Scadden were among 65 new members elected worldwide.
Scadden, who received his undergraduate degree from Bucknell University in Pennsylvania, currently resides in Weston, Mass.
Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of nearly $500 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, transplantation biology and photomedicine. MGH and Brigham and Women's Hospital are founding members of Partners HealthCare HealthCare System, a Boston-based integrated health care delivery system.
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