October 23, 2008

Case Western Reserve University's Clinical and Translational Science Collaborative funds pilot studies

Cleveland CTSA awards more than $430,000 to local research efforts


The Case Western Reserve University Clinical and Translational Science Collaborative (CTSC) has announced the recipients of its 2008 Pilot Project grants. Seven researchers received pilot awards totaling $430,143 from the CTSC to fund early clinical studies in translational science.

The CTSC, in its second year, is Cleveland's $64 million Clinical and Translational Science Award (CTSA) to Case Western Reserve University from the National Center for Research Resources (NCRR) of the National Institutes of Health (NIH). Case Western Reserve University coined its award the Clinical and Tranlations Science Collaborative, as it is a collaboration between Case Western Reserve University, Cleveland Clinic, MetroHealth Medical Center and University Hospitals.

"The goal of the Clinical and Translational Science Collaborative is to catalyze the clinical and translational research of the future, and particularly to capitalize on new technologies to advance human health. These projects exemplify the use of new approaches to solve stubborn problems such as why cancer metastasizes and how the brain is damaged in degenerative diseases," said Pamela Davis, M.D., Ph.D., Principal Investigator of the CTSC and Dean of the School of Medicine. "It is our goal that this seed money can grow full-blown projects to solve these difficult questions."

Funding for this pilot project award comes directly from the $64 million awarded to Case Western Reserve University in September of 2007. The center's Scientific Review Committee and Executive Committee selected the 2008 pilot projects from more than 30 proposals submitted in July. Preference was given to proposals that were interdisciplinary or inter-institutional in nature; all of the recipients have strong collaborators associated with their projects. The recipients are:

  • John Kirwan, Ph.D., Cleveland Clinic Lerner College of Medicine of Case Western Reserve University's Department of Molecular Medicine, Insulin Resistance: Detection of Hepatocellular Lipid Sub-Species by Magnetic Resonance Spectroscopy
  • Henry B. Koon, M.D. Assistant Professor Medicine, Ireland Cancer Center/University Hospitals of Cleveland, Identification of genomic lesions promoting nodal metastasis in malignant melanoma
  • W. H. Wilson Tang, M.D., Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Staff Cardiologist, Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Heart and Vascular Institute, Understanding Disease Progression in Inherited Cardiomyopathies: Detection and Longitudinal Monitoring of Hypertrophic Cardiomyopathy in Heterozygous MYBPC3 Mutation Carriers in the Geauga County Amish Community
  • Mark D. Adams, Ph.D., Associate Professor, Department of Genetics, Case Western Reserve University School of Medicine, Development of a Rapid Molecular Assay to Predict Antibiotic Susceptibility in the Nosocomial Pathogen Acinetobacter baumannii
  • James P. Basilion, Ph.D., Associate Professor of Radiology and of Biomedical Engineering, Case Western Reserve University Schools of Medicine and Engineering, Molecular Imaging of Dysplasia in Barrett's Esophagus
  • Donna Hansel M.D., Ph.D., Assistant Professor of Anatomic Pathology, Glickman Urological and Kidney Institute and Taussig Cancer Institute at the Cleveland Clinic, mTOR Phosphorylation and Associated Upstream PTEN Alterations in the Prediction of Urothelial Carcinoma Metastases and Patient Outcomes
  • Amy Wilson-Delfosse, Ph.D., Associate Professor, Department of Pharmacology,Case Western Reserve University School of Medicine, Establishment of a CTSC Parkinson's Disease Phenotypic and Genotypic Registry

For more information and/or to learn more about eligibility, application and awards given, go to www.clevelandctsc.org.

For more information contact Christina Thompson DeAngelis, 216.368.3635.

For more information contact Jessica E. Studeny, 216.368.4692.

Posted by: Kimyette Finley, October 23, 2008 10:36 AM | News Topics: Cleveland Clinic Lerner College of Medicine, Collaborations/Partnerships, Faculty, Grants, HeadlinesMain, Research, School of Medicine, news

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