NIH Awards $6.4M to Case Western Reserve School of Medicine Researchers

Case Western Reserve University School of Medicine faculty members are reaping the rewards of funding from the National Institutes of Health (NIH), in the form of grants and contracts. The funding totals more than $6.4 million for four different research endeavors. 

Mark Chance

Researchers Mark Chance, PhD, professor of physiology and biophysics, director of the Center for Proteomics and Bioinformatics, and interim chair of the Department of Genetics, and W. Henry Boom, MD, professor of medicine and director of the Tuberculosis Research Unit, are working to tackle the easily transmissible, and often deadly, Mycobacterium tuberculosis (MTB). They received a grant for more than $750,000 from the NIH, with the potential to receive up to $2.8 million over the next four years.

The Case Comprehensive Cancer Center was awarded a new $2.5 million grant from the National Cancer Institute (NCI) to evaluate the introduction and expression of the modified MGMT gene in hematopoietic stem cells in an effort to improve efficacy of chemotherapy for glioblastoma multiforme (GBM), the most common and most aggressive type of primary brain tumor in humans. The current treatment therapy is hampered by the dose-limiting bone marrow toxicity. This Phase I clinical trial will enable bone marrow to repair DNA alkylation, which is produced by concurrent radiation and temozolomide chemotherapy, by allowing patients to tolerate higher doses of chemotherapy. 

W. Henry Boom

In another example of a team science approach, members of the Case Comprehensive Cancer Center have been tapped to join an important NCI multisite prospective study of all grade II, III and IV glioma patients within the state. With a NIH-awarded contract of $715,000 with the potential for an extension leading to more than $2.5 million, researchers will be part of The Cancer Genome Atlas (TCGA) Project, which is a national comprehensive and coordinated effort to accelerate understanding of the genetics of cancer using innovative genome analysis technologies.

The Department of Bioethics was awarded a $2.5 million continuation grant from the National Human Genome Research Institute that will extend funding for its Center for Genetic Research Ethics and Law (CGREAL) for an additional four years. The School of Medicine’s CGREAL is a national NIH Center of Excellence in Ethical, Legal, and Social Issues (ELSI) Research, which includes more than 20 faculty members across multiple academic departments, clinical units, and institutions in Northeast Ohio. Read more.

Campus News

There will be an interruption of services for PeopleSoft HCM and Financials users between 8 a.m. and 6 p.m. on Saturday. This is to allow Information Technology Services (ITS) to upgrade the servers that those critical systems reside on. During this time both PeopleSoft HCM and PeopleSoft Financials be unavailable. If you have additional questions about this outage please contact the ITS Help Desk 368.HELP (4357) or go to

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The Clinical and Translational Science Collaborative (CTSC) of Case Western Reserve University and the Case Coulter Translational Research Partnership (CCTRP) competition for CTSC Annual Pilot Grant Funding of up to $50,000 to support innovative translational research projects focused upon the invention, preclinical development and/or first in man studies of novel therapeutic agents, biomedical devices and diagnostics designed to address unmet clinical needs.

The CTSC and CCTRP will provide seed money to faculty in multidisciplinary programs for pilot projects that will lead to efficient use of resources and support of inter-institutional, clinical translational research in Cleveland. Investigators in the basic science and clinical departments at Case Western Reserve University, Cleveland Clinic, MetroHealth Medical Center, University Hospitals and the Louis Stokes Cleveland VA Medical Center are eligible.

The CTSC Annual Pilot Program is now a two-step process.  Step 1 is to submit a Letter of Intent (LOI) as outlined in the RFA via the electronic system, WebGrants. This deadline is Jan. 15.  Researchers whose proposals meet the requirements of the RFA and best reflect the goals of the CTSC Annual Pilot Grant Program will be invited to submit a full application (Step 2). Deadline for submission of the full application is March 15. For instructions on how to apply and to learn more about the Annual Pilot Grant Program, please visit the website

For Faculty and Staff

The Department of Human Resources’ Employee Education, Training and Development Unit provides a vast array of on-campus training and education opportunities.  Learn more online.

For Students

Undergraduate students: If you need your spring 2011 RTA pass prior to leaving campus this month, please email your request. We will email you when the pass is ready for pickup at Access Services. Graduate students may purchase spring 2011 RTA passes at Access Services for $75. Spring RTA passes are valid from Jan. 6 to May 20.

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Dig in for a late-night breakfast 9:30-11 p.m. Thursday at Leutner and Fribley. All undergraduates are eligible; no meal plan is needed.

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The University Counseling Services is announcing its first graduate student support group to be offered the second Tuesday of every month from noon to 1:15 p.m. beginning next Tuesday in the Spartan Room. The group will be facilitated by staff psychologist Pamela Nilsson of the University Counseling Services. All graduate and professional school students are welcome. Pizza and soft drinks will be served.


In cooperation with the Cleveland Museum of Natural History, the Cleveland Astronomical Society and with the support of the Arthur S. Holden Sr. Endowment, the Department of Astronomy is presenting the 2010-11 Frontiers of Astronomy Lecture Series. Stacy S. McGaugh, University of Maryland, will  present The Driving Role of Gravity in Cosmology at 8 p.m. Thursday at the Natural History Museum. Renowned astronomers from across the country will give free lectures at the Cleveland Museum of Natural History in this series. More information on the series is available online.

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Science Cafe Cleveland presents Fire, fish, and flow: from burning rivers to living rivers at 6:30 p.m. Dec. 13 at the Great Lakes Brewing Company Tasting Room, 2701 Carroll Ave. The event sponsored by Case Western Reserve University, WCPN ideastream and Great Lakes Brewing Company. In this talk, Jeff Opperman of The Nature Conservancy will summarize recent advances in the science of rivers and describe how the conservancy and partners are working to find sustainable solutions for providing water and energy while maintaining and restoring healthy rivers.


The views and opinions of those invited to speak on campus do not necessarily reflect the views of the university administration or any other segment of the university community.

Et al.

Deborah Jacobson

Assistant professor Deborah Jacobson will be leading a panel presentation with Case Western Reserve students on Micro-credit and Social Development in Bangladesh: Study Abroad Program, for the conference of The International Consortium for Social Development (ICSD) in Dhaka, Bangladesh, in January. The ICSD is an organization of practitioners, scholars and students in the human services and meets every other year in a different country. There will be 17 students from Case Western Reserve University on the study abroad course to Bangladesh this year and they will each have a chance to participate in the conference as part of the program. More information is available online.

Dec. 8, 2010

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In the News

Universities ease final exam stress with innovative programs, Dec. 8, 2010
Universities are stepping up to help students deal with the stress of final exams. Melanie Scanlon, assistant director for student activities and leadership at Case Western Reserve University, said: “We realize finals can be a stressful time. We want to make sure students are mentally healthy and take time for breaks and to eat. They need to take care of themselves.”

NIH awards $6.4 million to Case Western Reserve School of Medicine researchers, Dec. 7, 2010
Case Western Reserve University School of Medicine faculty members have been awarded grants and contracts from the National Institutes of Health (NIH) of more than $6.4 million for four different research endeavors.

Onychomycosis Update, Dec. 6, 2010
Research conducted by Mahmoud Ghannoum, PhD, at Case Western Reserve University's Center for Medical Mycology led to the development of  new treatment for Onychomycosis, a fungal infection of human nails. A clinical trial is planned for early 2011. 

Higher Ed News

Colleges and Students Would Benefit From Tax Compromise

Chronicle of Higher Ed, Dec. 7, 2010
A compromise President Obama has reached with Republicans would extend for two years a series of tax benefits, including a research-and-development tax credit and a trio of deductions and credits for college tuition.