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Entries for July 2007

July 31, 2007

The dangerous consequences of a militarized foreign policy

Chalmers Johnson is a former CIA consultant and a professor of Asian studies at Berkeley, and was an avowed cold-war warrior during the Vietnam war era. He has written a very interesting article titled Evil Empire: Is Imperial Liquidation Possible for America? He points out the Iraq war as an unmitigated disaster on many levels and the failure of the media as culpable.

The people of the United States became mere spectators as an array of ideological extremists, vested interests, and foreign operatives -- including domestic neoconservatives, Ahmed Chalabi and his Iraqi exiles, the Israeli Lobby, the petroleum and automobile industries, warmongers and profiteers allied with the military-industrial complex, and the entrenched interests of the professional military establishment -- essentially hijacked the government.
. . .
One subject that the government, the military, and the news media try to avoid like the plague is the racist and murderous culture of rank-and-file American troops when operating abroad. Partly as a result of the background racism that is embedded in many Americans' mental make-up and the propaganda of American imperialism that is drummed into recruits during military training, they do not see assaults on unarmed "rag heads" or "hajis" as murder. . . Some militarists will reply that such inhumanity to the defenseless is always inculcated into the properly trained soldier.
. . .
Imperialism and militarism have thus begun to imperil both the financial and social well-being of our republic. What the country desperately needs is a popular movement to rebuild the Constitutional system and subject the government once again to the discipline of checks and balances. Neither the replacement of one political party by the other, nor protectionist economic policies aimed at rescuing what's left of our manufacturing economy will correct what has gone wrong. Both of these solutions fail to address the root cause of our national decline.

I believe that there is only one solution to the crisis we face. The American people must make the decision to dismantle both the empire that has been created in their name and the huge (still growing) military establishment that undergirds it.

He points to the hidden and bloated budget of the defense department and calls for a dismantling of the vast network of foreign military bases stretched over the globe. Many people are unaware of the vastness of the network of military bases that the US maintains around the world, emblematic of a nation that sees itself as an empire. Johnson sees this notion of empire as having disastrous long-term consequences and calls for a scaling back.

As part of the process of de-garrisoning the planet and liquidating our empire, we would have to launch an orderly closing-up process for at least 700 of the 737 military bases we maintain (by official Pentagon count) in over 130 foreign countries on every continent except Antarctica.
. . .
Equally important, we should rewrite all our Status of Forces Agreements -- those American-dictated "agreements" that exempt our troops based in foreign countries from local criminal laws, taxes, immigration controls, anti-pollution legislation, and anything else the American military can think of. It must be established as a matter of principle and law that American forces stationed outside the U.S. will deal with their host nations on a basis of equality, not of extraterritorial privilege.
. . .
As part of an attempt to right the diplomatic balance, we should take some obvious steps like recognizing Cuba and ending our blockade of that island and, in the Middle East, working to equalize aid to Israel and Palestine, while attempting to broker a real solution to that disastrous situation. Our goal should be a return to leading by example -- and by sound arguments -- rather than by continual resort to unilateral armed force and repeated foreign military interventions.
. . .
Normally, a proposed list of reforms like this would simply be rejected as utopian. I understand this reaction. I do want to stress, however, that failure to undertake such reforms would mean condemning the United States to the fate that befell the Roman Republic and all other empires since then. That is why I gave my book Nemesis the subtitle "The Last Days of the American Republic."

The whole article is well worth reading.

POST SCRIPT: Tom Friedman's moustache of understanding

Tom Tomorrow's cartoon describes the 'thinking' of one of the most over-rated pundits, the originator of an endless stream of banalities and the famous Friedman Unit, in which one always waits for another six months to get enough information to make a decision.

July 30, 2007

Evolution-16: The evolution of the eye

(Please see here for previous posts in this series.)

The eye is one organ almost invariably brought out by creationists to argue against evolution. How could something so complex have possibly evolved incrementally, they ask?

Darwin himself suggested the way that the eye could come into being. Due to the fact that eyes don't fossilize and thus leave a permanent record, it is hard to trace back in time and see the various stages in the evolution of the eye as linear developments. So he looked instead at the eyes of currently existing different organisms at intermediate stages of development, and concluded (On the Origin of Species, 1859, p. 188):

With these facts, here, far too briefly and imperfectly given, which show that there is much graduated diversity in the eyes of living crustaceans, and bearing in mind how small the number of living animals is in proportion to those which have become instinct, I can see no very great difficulty (not more than that in the case of many other creatures) in believing that natural selection has converted the simple apparatus of an optic nerve merely coated with pigment and invested with transparent membrane, into an optical instrument as perfect as is possessed by any member of the great Articulate class.

Steven Pinker (How The Mind Works, 1997, p. 159) describes how Darwin established how the eye could have evolved, according to the step-by-step process that I have described earlier, each step having a low probability for an individual but becoming likely when large numbers of organisms are involved over long times.

By looking at organisms with simpler eyes, Darwin reconstructed how that could have happened. A few mutations made a patch of skin cells light sensitive, a few more made the underlying tissue opaque, others deepened it into a cup and then spherical hollow. Subsequent mutations added a thin translucent cover, which subsequently was thickened into a lens, and so on. Each step offered a small improvement in vision. Each mutation was improbable, but not astronomically so. The entire sequence was not astronomically impossible because the mutations were not dealt all at once like a big gin rummy hand; each beneficial mutation was added to a set of prior ones that had been selected over the eons.

Still think it is implausible? Once again, using mathematics and computer simulations based on strict natural selection principles and starting, as Darwin himself suggested, with a light-sensitive nerve, it is possible to estimate how long the process of eye evolution took (Pinker, p.164):

The computer scientists Dan Nilsson and Susanne Pelger simulated a three-layer slab of virtual skin resembling a light-sensitive spot on a primitive organism. It was a simple sandwich made up of a layer of pigmented cells on the bottom, a layer of light sensitive cells above it, and a layer of translucent cells forming a protective cover. The translucent cells could undergo random mutations of their refractive index: their ability to bend light, which is real life often corresponds to density. All the cells could undergo small mutations affecting their size and thickness. In the simulation, the cells in the slab were allowed to mutate randomly, and after each round of mutation the program calculated the spatial resolution of an image projected onto the slab by a nearby object. If a bout of mutations improved the resolution, the mutations were retained as the starting point for the next bout, as if the slab belonged to a lineage of organisms whose survival depended on reacting to looming predators. As in real evolution, there was no master plan or project scheduling. The organism could not put up with a less effective detector in the short run even if its patience would have been rewarded by the best conceivable detector in the long run. Every change had to be an improvement.

Satisfyingly, the model evolved into a complex eye right on the computer screen. The slab indented and then deepened into a cup; the transparent layer thickened to fill the cup and bulged out to form a cornea. Inside the clear filling, a spherical lens with a higher refractive index emerged in just the right place, resembling in many subtle details the excellent optical design of a fish's eye. To estimate how long it would take in real time, rather than compute time, for an eye to unfold, Nilsson and Pelger built in pessimistic assumptions about heritability, variation in the population, and the size of the selective advantage, and even forced the mutations to take place in only one part of the "eye" each generation. Nonetheless, the entire sequence in which flat skin became a complex eye took only four hundred thousand generations, a geological instant.

In his book The Ancestor's Tale, Richard Dawkins points out (p. 388) that after the evolution of light-sensitive cells in worms about 600 million years ago, the kinds of image-forming optics that we now call the eye is estimated to have independently evolved more than 40 different times in various parts of the animal kingdom. Vastly different eye forms like the human eye and the compound eye of the crustaceans evolved differently and independently from a primitive common light sensitive cell that formed a proto-eye.

So far from being an event of unimaginably breathtaking improbability, the evolution of the eye is relatively mundane, although the organ itself is quite remarakable.

That is exactly the point that those opposed to natural selection refuse to acknowledge when they act as if all the parts of the eye must have come together almost at once. What is highly improbable to happen in one fell swoop becomes possible when it happens gradually.

Richard Dawkins in his book Climbing Mount Improbable looks at case after case of things that seem to be very complex and how they could have come about by natural selection. But Darwin did not need Dawkins to be convinced. In his own day, he had enough evidence to satisfy him. "If it could be demonstrated that any complex organ existed, which could not possibly have formed by numerous, successive, slight modifications, my theory would absolutely break down. But I can find no such case." (Darwin, p. 189)

He further added (Darwin, p. 109): "Slow though the process of selection may be, if feeble man can do so much by his powers of artificial selection, I can see no limit to the amount of change, to the beauty and infinite complexity of the coadaptations between all organic beings, one with another and with their physical conditions of life, which may be effected in the long course of time by nature's power of selection."

POST SCRIPT: Great moments in the evolution of technology

Have you seen the the sideways bike?

July 27, 2007

Evolution-15: How species evolve

(Please see here for previous posts in this series.)

The final feature that needs to be addressed is the probability of mutations cumulating to produce new organs and species.

This question lies at the heart of many people's objections to evolutionary ideas. They cannot envisage how infinitesimal changes, each invisible to the eye, can add up to major changes. That is because they tend to think that the two foundations for this to occur (the occurrence of successful mutations and the mutations then spreading throughout the population) are both highly unlikely, and so that the chance of a whole sequence of such processes occurring must be infinitesimally small.

What this series of posts has shown is that given large population sizes and the long geological times available, not only are those two things not unlikely, they are almost inevitable. The mathematical results discussed in the previous posts have shown two very important results. The first is that when the large sizes of populations and the long times involved are taken into account, the probability of favorable mutations occurring is quite high. The second is that the probability of a single favorable mutation spreading to every organism in the population is also high. These two results undercut the arguments of those who simply throw their hands up in the air and declare that evolution is extremely unlikely to have occurred.

Once that is understood, it is not hard to see how successive mutations that each have a selection advantage can pile one on top of another to produce new species leading to the diverse and complex biological system that we see today. The history of twentieth century biology is the discovery of case after case of the evolutionary history of organisms. Richard Dawkins's book Climbing Mount Improbable describes many such cases.

In order to understand how speciation comes about, we need to understand better what constitutes different species. As pointed out by biologist Steve Jones, "Species are divided from each other in many different ways – by space, by time, by mating preference, by the inability to fertilize an egg or produce healthy young, or by the sterility of the offspring." (Almost Like a Whale, p. 231)

The most famous historical example is that of the finches of the Galapagos Islands. During his five year trip on the Beagle Darwin had periodically shipped various specimens back to England to specialists to study them, and a respected ornithologist John Gould had agreed to study the birds. Soon after his return to England in 1836, Darwin met with Gould who gave him the surprising news that birds that Darwin had thought were different species like wrens and finches and orioles were actually all different kinds of finches. Furthermore, Gould had also found among Darwin's specimens three mockingbird species, each set of which came from a different island in the Galapagos. (The Reluctant Mr. Darwin, David Quammen, (2006), p. 24)

This fueled Darwin's suspicions that these birds had evolved from a single species that had somehow made the difficult journey to the Galapagos from the South American mainland, and after spreading out to each island had then become isolated from the others and evolved into separate species under the different selection pressures they experienced on the different islands.

Darwin decided to devote himself to the study of speciation and in order to do so, started with the breeding of animals in captivity. He extensively studied another bird (the pigeon) that was highly popular among breeders in England at that time and for which there existed a huge number of breeds. By studying pigeons (the first chapter of On the Origin of Species deals exhaustively with them), Darwin satisfied himself that all the species of pigeons were descended from a single type, the rock pigeon. "Great as the differences are between the breeds of pigeons, I am fully convinced that the common opinion of naturalists is correct, namely, that all have descended from the rock-pigeon (Columba livia)." (On the Origin of Species, Charles Darwin, (1859), p. 23)

In an interesting follow up to the Darwin finch story, Rosemary and Peter Grant spent twenty years in the Galapagos studying the finches and they actually observed the evolution that Darwin could only speculate about. For example, Darwin had noticed that the finches' beaks "resembled different kinds of pliers: heavy duty lineman's pliers, high-leverage diagonal pliers, straight needle-nose pliers, curved needle-nose pliers, and so on. Darwin eventually reasoned that one kind of bird was blown to the islands and then differentiated into thirteen species because of the demands of different ways of life on different parts of the island, such as stripping bark from trees to get at insects, probing cactus flowers, or cracking tough seeds." (How the Mind Works, Steven Pinker (1997), p. 163)

Darwin felt that such changes would occur too slowly to be observed. But what the Grants did 150 years later was to show that such changes could in fact be observed in real time. They "painstakingly measured the size and toughness of the seeds in different parts of the Galapagos at different times of the year, the length of the finches' beaks, the time they took to crack the seeds, the numbers and ages of the finches in different parts of the islands, and so on – every variable relevant to natural selection. Their measurements showed the beaks evolving to track changes in the availability of different kinds of seeds, a frame-by-frame analysis of a movie that Darwin could only imagine." (Pinker, p. 163)

Evolution is a fact. Natural selection is far and away the only theory that comes even close to explaining in detail how it happened, although will always be many things as yet unexplained. As biologist Steve Jones writes, "Although biologists still argue about how the process works, fossils make it impossible for anyone, biologist or not, to deny that it happened." (Almost like a Whale, 1999, p. 306)

Next in the series: The evolution of the eye

POST SCRIPT: The Darwin Year 2008-2009

This series of posts was inspired by the fact that 2009 will be the 200th birth anniversary of Charles Darwin and the 150th anniversary of the publication of On the Origin of Species. Case is planning a year long celebration of this event for the 2008-2009 academic year.

As part of this, the Common Book Reading committee has selected David Quammen's The Reluctant Mr. Darwin as the book that all incoming first-year students in fall 2008 read, and will also try to expand the program to make it a campus-wide reading experience.

Quammen has agreed to be the fall convocation speaker in September 2008. There are also plans to have E. O. Wilson (one of the most eminent evolutionary biologists and author of Sociobiology), Sean B. Carroll (The Making of the Fittest), and Rosemary and Peter Grant also give talks during that year.

July 26, 2007

Single payer health universal insurance coming to Ohio?

(For previous posts on the topic of health care, see here.)

Efforts are underway to try get a universal, single payer health care system in Ohio. The group behind it is the Single-Payer Action Network Ohio (SPAN Ohio), which is supporting legislation instituting such a plan. Their website provides more information about their initiatives and meetings.

The Health Care for All Ohioans Act has been introduced in the Ohio House (H. B. 186) and the Senate (S. B. 168).

The main points of the legislation can be seen here but here are the highlights:

  • Patients get free choice of health care providers and hospitals.
  • When you go to your own personal physician for visits, there are NO premiums, NO co-payments, NO deductibles, NO one excluded. You pay nothing.
  • When you get your prescription filled by your pharmacist, there are NO premiums, NO co-payments, NO deductibles, NO one excluded. You pay nothing.
  • If you need hospitalization, there are NO premiums, NO co-payments, NO deductibles, NO one excluded. You pay nothing.

In each case, the health care provider is reimbursed from the Ohio Health Care Fund.

So how does the Ohio Health Care Fund get its money? Under the proposed plan, people who earn less than the Social Security tax cap (currently $97,500 per year) pay no additional taxes. The money to fund the system comes from a variety of sources: up to 3.85% payroll tax paid by employers; up to 3% gross receipts tax paid by businesses; 6.2% tax on individual compensation in excess of the Social Security tax cap; 5% surtax on adjusted gross income over $200,000; funds from other government sources. Remember that currently employers that provide private health insurance have to pay for it. That money can now be directed to the Ohio Health Care Fund instead.

An Ohio health care agency runs the program and its governing board consists of the state director of health and fourteen other members, two from each of the seven regions that make up the state. The two members are elected for two-year terms by a regional health advisory committee, which in turn is elected by a meeting convened of the county and city health commissioners of each region.

Since there are many misconceptions (often deliberately perpetrated by the health care industry and its allies in the media) about what a single payer system involves, here is a handy document that compares the myths with the realities.

One of the big distortions that will be perpetrated by the health insurance and drug industries and politicians is to treat 'universal' and 'single-payer' as if they are synonymous terms. They are not and people should be vigilant when that sleight-of-hand is attempted. 'Universal' refers to the fact that every person should be covered, with no exceptions. 'Single payer' refers to the mechanism by which the health care system is financed and health care providers reimbursed.

It is not difficult to provide 'universal' private health insurance coverage, if that coverage is bad. All one needs to do to achieve that is to compel everyone to purchase some kind of health insurance, like the way people are compelled to buy auto insurance in order to drive, and some states have gone that route. But all that achieves is people or their employers being forced to purchase high-deductible, low-treatment coverage. Such policies will not result in better and more accessible treatment for more people or reduce the frustrating bureaucracy that we all encounter now. In fact, it will be a profit windfall for the private insurance companies as they get even more people into their nets. Such 'universal' programs would not be an improvement on the current system, though it will be touted as such by the health-care industry and their apologists.

'Single-payer' means something different, that there should be just one single entity, preferably run by the government or at the very least a non-profit publicly accountable board, that collects the money and spends it on the health care system. The single payer plan calls for the complete elimination of profit-driven private health insurance companies from the health care system, and has to be an essential component of any meaningful health care reform. As Sicko pointed out, the introduction of profit-making bodies between the patient and the doctor is the single feature that has resulted in the health care system in the US being so inferior to its peer countries.

Candidates should not be able to evade the issue by saying they support universal health-care. The question that should be asked is whether they support single-payer universal health care. Of all the presidential candidates in both parties, only Dennis Kucinich is calling for such a universal single-payer system, although many of the other Democratic candidates have signed onto the vague 'universal' health care part.

A petition has also been started by SPAN Ohio to gather signatures to put the legislation onto the statewide ballot. This petition contains the officially approved summary of what the legislation contains, as well as the full text of the bill. It is a parallel track strategy to the bills in the state legislature to get the same results.

I am collecting petition signatures so if anyone wants to sign it, or collect signatures as well, please contact me or SPAN Ohio. My petition form is limited to those who reside in Cuyahoga County.

The Cleveland branch of SPAN Ohio meets at 7:00pm on the first Monday of each month at the ACLU building, 4506 Chester Avenue. Other branch locations and meeting times can be found on their website.

POST SCRIPT: Handy guide to candidates

With so many people running for president, it is hard to compare their stands on the various issues. One enterprising website has done us all a favor by preparing a table that gives capsule summaries of their views. Of course, you will need to look elsewhere for more details and nuances.

July 25, 2007

Evolution-14: How a single mutation spreads everywhere

In the previous post, we saw that if we start with a trait that is present in just 0.1% of the population (i.e., f=0.001), and if this has a small selection advantage of size s=0.01, this will grow to 99.9% (F=0.999) in just under 1,400 generations, which is a very short time on the geological scale.

But in a population of one million, an initial fraction of f=0.001 means that we are starting with about 1000 organisms having the favorable mutation. But it could be argued that new mutations usually start with just a single new kind of organism being produced in one single organism. How does that affect the calculation?

Suppose that you have a population of organisms of size N and they all start out having the same gene at a particular position (called the 'locus') on one of the chromosomes that make up the DNA. Now suppose a random mutation occurs in just one organism, the way that it was described in an earlier post in this series describing the shift from violet to UV sensitive sight in some birds. Most of the time, even a favorable mutation will disappear because of random chance because (say) that mutated organism died before it produced any offspring or it did produce a few and that particular gene was not inherited. But on occasion that mutation will spread. How likely is it that such a single mutation will spread to every single organism (i.e., become 'fixed' in the population)?

When one is not dealing with deterministic systems involving smoothly varying numbers (as was done in the previous case), a different kind of calculation (based on probabilities and known as 'stochastic') has to be done, and in this case the expectation value for the number of generations T taken for the single new mutation to spread all over and become fixed in the population (i.e. to spread to 100% of the organisms) is given by T=(2/s)ln(2N) generations, where 'ln' stands for natural logarithms. (Molecular Evolution, Wen-Hsiung Li, 1997, p. 49)

Even if s is taken as a very small advantage of size 0.01, for a population of N=one million, the average time taken for just a single mutation to become fixed is just 2,900 generations. So we see that mutations occurring in a single organism can become universal in a very short period on the geological time scale.

There are two important points that need to be emphasized.

There first is that even a very small selection advantage is sufficient to have that mutation dominate the species. This means that the advantage may not be even visible in the organism itself, which may look like every other organism in the species. For example, an eye mutation that works better by just a tiny bit may look like every other eye. Thus we should not think in terms of big changes for natural selection to work.

The second point is that even starting from a single mutation, as long as it takes hold (which has a probability of 2s of happening) and does not disappear and has an selection advantage however small, the mutation can spread surprisingly rapidly in the population and become universal and form the basis for future mutations.

It is interesting that even if there is no survival advantage to the new gene (i.e., s=0 and the mutation is said to be 'neutral'), the mutation can on occasion still spread and become fixed, except that now the average time taken is much longer and given by T=4N generations. So that for a population of one million it would take on average about 4 million generations for a neutral mutation to spread everywhere, as compared to just 2,900 generations for a selection advantage of 0.01.

Darwin did not have access to this kind of mathematical analysis, which came long after his death. It is a tribute to his genius that he intuitively sensed the power of cumulative change over long time scales.

So far, I have shown how the first two items in the three components of natural selection, although seeming to have small probabilities of occurring, actually are quite likely. The third aspect of natural selection that has to be looked at is how the cumulative effects of small changes lead to big changes.

POST SCRIPT: Some real fact-checking

In yesterday's post, I spoke about how the media does almost no fact-checking on Bush. Well, except for Jon Stewart who catches Bushies making up stuff about Iraq.

July 24, 2007

CNN, Michael Moore, Sicko, and fact-checking as propaganda tool

(For previous posts on the topic of health care, see here.)

All Michael Moore's films deal with very serious topics in ways that are both informative and entertaining. His films have dealt with corporate greed, violence in society, the Iraq war, and now the health industry. Along with Robert Greenwald's Brave New Films, he provides a perspective and viewpoint that is almost completely absent from the mainstream media.

What is curious is the response to his films. People seem to find it hard to accept that his critiques are largely accurate and desperately seek to find something, however trivial or immaterial to his main point, that is wrong so that they can discredit his entire case. They seem to be eager to characterize Moore as not being a "serious" person.

The so-called "fact-checking" by CNN medical correspondent Sanjay Gupta, for example, has to be seen to be believed. He accused Moore of "fudging facts" but got his own facts wrong, and the only "expert" his report showed was an academic who did business with the medical industry, although this fact was not pointed out. Gupta accused Moore of cherry-picking data, when the same charge could be leveled at CNN, and the differences in any case were small and immaterial to the case Moore was making.

I am all for fact-checking statements made by public figures, and Moore should not be exempted. But the point is that while CNN enthusiastically "fact-checks" anti-establishment figures like Moore, they almost never do similar things for the statements by government and industry personnel. This is characteristic of the media propaganda model that was pointed out by Noam Chomsky and Edward Herman in the classic work Manufacturing Consent. Moore rightly chastised Blitzer for the fact that the mainstream media uncritically passed on all the outrageous statements by Iraq war advocates leading up to the 2003 invasion. They are doing a similar thing now with respect to Iran. Where is their vaunted "fact-checking" on those important issues? To find any serious fact-checking of statements by Bush or Cheney or any administration spokespersons, one needs to read blogs.

There is no question that big media outlets are completely beholden to the medical and drug industries because of the extensive advertising revenue they receive from them, and thus avoid taking a hard line against them. If Gupta or Blitzer did a really serious comparison of the US and (say) French health care systems and concluded that the French were better, the CNN top brass would get stern calls from the health-related industry and they would feel the heat. The point is not that Blitzer and Gupta are deliberately hiding the truth (though that might be the case), it is that the way the media filters operate is that only people who think like them, who are already sympathetic to the US health care industry and will bend over backwards to show them in a good light, will get to the position they currently occupy. So the fact that they effectively act as shills for the health industry should not come as a surprise. (See my previous post and here for more on how the media works.)

It seems that if you are well-dressed, articulate person from a so-called "respectable" institution like a think-tank or government or academia or the media (I am thinking of people like William Kristol, Charles Krauthammer, Mitt Romney, Alan Dershowitz, Rudy Giuliani, Joe Lieberman, and the innumerable loyal Bushies and Cheneyites), you can say the most outrageous, even borderline insane, things (such as advocate torture and indefinite detention without trial or access to lawyers, undermine the Bill or Rights, attack Iran, link Iraq to al Qaeda and 9/11, and not even rule out the use of nuclear weapons) without being challenged and fact-checked, as long as you are promoting the pro-establishment or pro-war or pro-business point of view. Running fact-checks on what these people say, especially George Bush during his public speeches and press conferences, would be very helpful but is rarely done.

But when it comes to Michael Moore, the mainstream media are eager to trot out their "fact-checking" teams to scrutinize him, because he is challenging the joint war/business establishment of which they are an integral part. The news media tends to assume that when Moore (a big fat guy in an open-neck shirt and unkempt hair stuffed under a baseball cap and looking like a trucker) comes ambling along, he must be simply shooting from the hip, as sloppy with the facts as he is with his appearance.

The reality is that Moore is a sharp guy who has a research team in place to back up the statements in his films. He is not a just-off-the-boat bumpkin that his cinematic persona projects and he knows that all the big establishment guns are just waiting for him to make a mistake so that they can pounce and use that single slip to discredit his whole thesis, a common tactic used by big corporations. It is not an accident that he can provide immediate refutations of Gupta's allegations. His research team has probably anticipated every possible challenge to his film and prepared a counter-offensive before even releasing the film. (CNN has now responded to Moore's charges against them.) See also Moore's website on the detailed documentation behind his film.

This is why CNN was reduced to desperately looking for something, anything, to support their contention that he "fudged the facts," and resorted to distortions when they couldn't find anything substantive. But people who condescend to Moore and take him lightly because he does not talk or look or act like a sophisticated intellectual are falling into a trap because they tend to underestimate him, and then are taken by surprise when he slaps them down with facts and reason, as Blitzer and Gupta experienced. When directly challenged, Gupta could not provide even a single example of how Moore "fudged the facts," and was reduced to whining about Moore using different sources for his data (even though all the sources used were authoritative) and how Moore described the health care systems of other nations as "free" when they were funded by taxes. This alone shows how far Gupta is stretching to try to discredit Moore. Does Gupta think we are so stupid that we believe that all the services we all commonly describe as "free" (libraries, parks, public schools etc.) magically appear as gifts from Santa Claus and are not funded by our taxes? The point is that "free" in those contexts is commonly understood as meaning that we can access those services at any time without having to produce cash or prove that we can pay.

And most importantly, in the other countries which have universal, single-payer health care systems, not a single person goes bankrupt or loses their home or has to forego other of life's essentials because of their health care needs. That is what "free" means, as Gupta must know but chooses to obfuscate.

In his report, Gupta also seemed to act like he had made a big journalistic scoop by 'discovering' that Cuba was at rank #39 (behind the US at rank #37) in the overall health care quality ranking. In fact, Moore's film clearly showed the two rankings. It was Gupta's CNN report that implied that Moore's film hid this fact by themselves hiding Cuba's on-screen ranking in the film behind a caption, as can be seen below where the left is from the film and the right is what was shown by CNN. This was a truly outrageous thing for a so-called journalist to do. So it was Gupta and CNN who were "fudging the facts."

sicko_facts_up_front_th.jpg cnn_covers_up_cuba_th.jpg

(Pam Martens points out that Gupta co-hosts a TV show called AccentHealth that is sponsored by drug companies likeMerck, whose products Gupta has been praising. And here is some background on Sanjay Gupta that suggests that he is a Deepak Chopra wannabe, using the same kind of medical-related, feel-good, pseudo-scientific mumbo-jumbo that seems to appeal to a lot of people.)

What I find odd is that even some people who share Moore's politics tend to try and distance themselves from him and treat him as a gadfly. One of the best analyses of the responses to Moore and his film was done by James Clay Fuller and it is well worth reading in its entirety. As Fuller says: "Apparently there is a rule in corporate journalism that every mention of Moore and his films, or Moore without his films, must contain at least two snide observations about his biases, his ever so naughty attacks on rich and powerful but somehow –- in the eyes of the corporate journalists -- defenseless people such as the chairman of General Motors, and, if you can slide it in, Moore's physical appearance." Another good analysis of the facts in Moore's film can be heard in this Fresh Air interview with Jonathan Oberlander.

You should really see Sicko if you have not already done so.

POST SCRIPT: Michael Moore with Stephen Colbert

It was a great interview. See the clip.

July 23, 2007

Evolution-13: Differential rates of survival

(Please see here for previous posts in this series.)

Of the three stages of natural selection outlined before, the only one that occurs purely by chance is the first one, that of the occurrence of mutations. I discussed how although the chances of producing a favorable mutation by changes in any individual site in the DNA (called 'point mutations') on an individual member of the species is very small, when the number of individuals in a species and the long times available for the changes to occur are factored into the calculation, the result is that such mutations are not only likely, they are almost inevitable to occur and furthermore are likely to occur many times.

The Hardy-Weinberg law showed that if natural selection was not at work (along with some other conditions), populations settled into stable equilibrium values after just one generation of random mating. The next question to be addressed is to see how the populations change when natural selection is allowed to act. How likely is it that favorable mutations produced in the set of genes (the genotype) that characterize the organism (the phenotype) will end up with that actual organism predominating in the species? (Recall that natural selection acts on the phenotype and not the genes directly, while mutations act only on the genes and inheritance is passed on purely via the genes. A genetic change that has no effect on the phenotype will not influence the fitness of the organism.)

It is not the case that this happens every time. Most mutations are deleterious and do not spread and even favorable changes usually disappear by chance before they can spread to become a significant number in the population. But when the favorable mutations do take hold, that particular variety becomes widespread and dominates the population.

There are many such cases that have occurred in nature. The most famous and widely quoted example of this kind of growth of a favored phenotype is the case of the peppered moths in industrial areas of England and America. As a result of the pollution that created dark backgrounds on the lichen covering the trees where the moths rested, the darker varieties of the moths were camouflaged better from predators than the lighter ones and thus had a significant survival advantage. From 1848 to 1896, the darker forms grew to as much as 98% of the population. Subsequently, with the advent of pollution control measures that cleaned up the environment and reduced the soot pollution, the dark moth population decreased to as low as 10%. In The Making of the Fittest (2006, p. 52-53), Sean B. Carroll points out that peppered moths are not the only such examples, that many similar changes in coloration due to selection pressures have occurred in land snails, ladybird beetles, desert mice, and other species.

The way that even a very small natural selection advantage can result in that variety dominating a species can be appreciated using the more familiar example of compound interest. Suppose a parent gives each of two children $1,000 at the same time. One of the children invests in a bank that offers an interest rate of 5.0% while the other, being slightly more thrifty, shops around and invests in a different bank at 5.1%. Although they start out with the total money being split 50-50, in 7,000 years the second child (or rather that child's descendents) will have 99.9% of the total money, thanks to that very small advantage in the annual rate of return.

It is exactly this kind of differential survival rate that plays such an important role in natural selection. Even minute differences in fitness can result, over the long term, in the runaway domination of a preferred variety. To see how fast this can happen, population geneticists have carried out calculations.

Suppose one variety has a mutated gene that has a very slight fitness advantage over the existing gene. 'Fitness advantage' can be quantified by defining the fitness w as the measure of the individual's ability to survive and reproduce. (The concept of fitness is a combination of the organism's ability to survive for any length of time (at least until its reproducing age is over) and its fecundity in terms of the number of offspring it produces.) Suppose the original gene has fitness w=1 and the new mutation has fitness w=1+s, where s is the selection advantage.

The selection advantage is a measure of how much more likely it is that that particular variety will propagate itself in future generations when compared with the standard type. So if, on average, the new mutated variety produces 101 fertile adult descendents while the same number of the standard organism produces 100, then s=0.01.

When this selection advantage is included in the calculation, the number of generations T it will take for a mutation to increase its frequency in the population from an initial value of f to a final value of F is given by the formula T=(1/s)ln[F(1-f)/f(1-F)], where 'ln' stands for the natural logarithm. (Molecular Evolution, Wen-Hsiung Li, 1997, p. 39)

So if we start with a trait that is present in just 0.1% of the population (i.e., f=0.001), and if this has a small selection advantage of size s=0.01, this variety will grow to 99.9% (F=0.999) of the population in just under 1,400 generations, which is a very short time on the geological scale.

But in a population of one million, an initial fraction of f=0.001 means that we are starting with about 1000 organisms having the favorable mutation. In reality, we are likely to begin with just one mutation in one organism. How does that affect the calculation?

That will be discussed in the next post in the series.

POST SCRIPT: Lil George and evolution

This clip from a cartoon show I had never heard of (probably because it is on cable) is pretty funny.

July 20, 2007

Evolution-12: Population genetics and the Hardy-Weinberg law

(Please see here for previous posts in this series.)

In the previous post, I discussed the puzzle posed by a naïve understanding of Mendelian genetics, which was that one might expect that organisms that displayed recessive gene traits would slowly disappear in a population while those with dominant gene traits would grow in number. But if that were true that would prevent new mutations from gaining a foothold in the population and growing in number, if it happened to be a recessive trait.

The crucial work that formed the breakthrough that revived the theory of natural selection was done in 1908 by G. H. Hardy (a Cambridge University mathematician and author of a fascinating book A Mathematician's Apology) and Wilhelm Weinberg (a German physician), working independently. What is nice is that the result is quite simple to derive, and surprising.

The main result is that whatever the distribution of gene pairs AA, Aa, and aa you start with in a population, after just one generation the number of people with those distributions will reach an equilibrium value that will never subsequently change. In other words, the numbers of the different types of genes in a population are stable. So traits, once they appear, do not disappear simply because of the accidents of random mating. This counters the 'blending inheritance' objections to Darwin's theory.

The proof of this result assumes that certain conditions apply so that only mating effects are at play: that the total population is large enough (effectively infinite for statistical purposes) to avoid the phenomenon of genetic drift, whereby the ratio of a particular gene varies purely due to statistical fluctuations (i.e., say the population with a particular gene happens to breed disproportionately, thus causing that gene's frequency to change), is diploid, that the population reproduces sexually and that mating within the population is totally random, that natural selection is not working to change the distributions of the genotypes, and that other factors like genetic mutations and migrations in or out of the population are not occurring (i.e., no gene flow).

Here's the result. Suppose that you start with a population in which AA types occur with probability p, Aa types occur with probability 2q (where the 2 is inserted just to make the arithmetic a little simpler), and aa types account occur with probability r. Since the total population must add to 100%, this means that the total probabilities p+2q+r=1.

Under the conditions given above, the Hardy-Weinberg result says that: (1) after just one generation, the AA types occur with probability P where P=(p+q)2, Aa with probability 2Q where Q=(p+q)(q+r), and aa with probability R where R=(q+r)2; and (2) these new probabilities will remain unchanged with each succeeding generation.

As an example, if we started with the population of AA being 50% (p=0.5), Aa being 40% (2q=0.4), and aa being 10% (r=0.1), then after just one generation, the Hardy-Weinberg result predicts that the proportions will be P=0.49 or 49% for AA, 2Q=0.42 or 42% for Aa, and R=0.09 or 9% for aa, and remain fixed at these values forever afterwards.

The proof of this result is quite simple and elegant and here it is:

If there is random mating, then the probability of any particular mating combination is just the product of their individual probabilities.

The probability of an AA mating with another AA is p2. The offspring will get just one gene from each parent, and in this case the result will always be AA.

The probability of an AA mating with an Aa is 4pq (the extra factor of 2 comes from the fact that this mating combination can occur two ways, that either the father could be AA and the mother Aa, or the father could be Aa and the mother AA) and there is a 50% chance that the offspring will be an AA and 50% chance of being an Aa.

Similarly, the probability of an AA mating with an aa is 2pr. The offspring will get just one gene from each parent, and in this case the result will always be Aa.

The probability of an Aa mating with an Aa is 4q2 and there is a 25% chance that the offspring will be AA, 50% chance of being an Aa, and 25% of being an aa.

The probability of an Aa mating with an aa is 4qr and there is a 50% chance that the offspring will be Aa and 50% chance of being an aa.

The probability of an aa mating with another aa is r2. The offspring will get just one gene from each parent, and in this case the result will always be aa.

When you add all the probabilities for each type of offspring together, the probabilities of getting AA and Aa and aa are just the expressions for P, 2Q, and R given above.

What Hardy and Weinberg noticed was that if, by some chance, the starting values p, q, and r were such that they satisfied the equation q2=pr, then after one generation, P=p, Q=q, and R=r. In other words, if the starting values satisfied that particular relationship, the probabilities are unchanged from one generation to the next.

Of course, the values of p, q, and r we actually start with for a random population can have any value, as long as p+2q+r=1. But after the first generation of mixing, the values P, Q, and R actually do satisfy the relationship Q2=PR, irrespective of the starting values of p, q, and r.

Since the values of P, Q, R that are obtained after one generation become the starting values to calculate the distributions for the subsequent generation, and since P, Q, R satisfy the required relationship Q2=PR, these values will remain the same for every succeeding generation after the first.

What I found particularly surprising is that usually equilibrium conditions tend to be approached gradually and even asymptotically. Here, whatever the starting point, you get equilibrium after just one iteration.

The stability of population distributions under conditions of random mating is an important result. It implies that gene distributions do not change due to mating but only under some kind of pressure to do so..

From the year 1908 onwards, mathematical biologists proceeded to make rapid advances in the embryonic field now known as population genetics. The names of R. A. Fisher, Sewall Wright, and J. B. S. Haldane are the ones associated with the birth of this field and by the 1930s or so, their work had put Darwinian natural selection and Mendelian genetics on a firm scientific and mathematical footing (William B. Provine, The Origins of Theoretical Population Genetics, 2001).

In the next post in the series, I will look at how natural selection causes the population distributions to shift.

POST SCRIPT: Iraq war lies

Watch this video to see the brazenness with which the country was lied into war.

July 19, 2007

Oh, and about those wait times for medical treatment. . .

When all their other arguments about the advantages of the current US health care system compared to universal, single-payer systems in France, Canada, England, Germany, etc. are shown to be false, apologists for the US health care system turn to their trump card: alleging that wait times to see a doctor in those countries is longer than it is in the US. This statement by the lobbying group America's Health Insurance Plans is typical: "The American people do not support a government takeover of the entire health-care system because they know that means long waits for rationed care."

The problem with this type of allegation is that the US does not systematically collect data on wait times, whereas the other countries do collect the data and make them public. The assumption seems to be that in the US, if there is no data, then the wait times must be zero. No data, no problem!

But using the scant data that is available, BusinessWeek points out that except in a few selected, non-emergency situations, even this charge is false: "In reality, both data and anecdotes show that the American people are already waiting as long or longer than patients living with universal health-care systems."

As Paul Krugman points out in his New York Times July 16, 2007 column:

[B]y and large, opponents of universal health care paint a glowing portrait of the American system that bears as little resemblance to reality as the scare stories they tell about health care in France, Britain, and Canada.

The claim that the uninsured can get all the care they need in emergency rooms is just the beginning. Beyond that is the myth that Americans who are lucky enough to have insurance never face long waits for medical care.
. . .
[N]ot all medical delays are created equal. In Canada and Britain, delays are caused by doctors trying to devote limited medical resources to the most urgent cases. In the United States, they're often caused by insurance companies trying to save money.

This can lead to ordeals like the one recently described by Mark Kleiman, a professor at U.C.L.A., who nearly died of cancer because his insurer kept delaying approval for a necessary biopsy. ''It was only later,'' writes Mr. Kleiman on his blog, ''that I discovered why the insurance company was stalling; I had an option, which I didn't know I had, to avoid all the approvals by going to 'Tier II,' which would have meant higher co-payments.''

He adds, ''I don't know how many people my insurance company waited to death that year, but I'm certain the number wasn't zero.''

(You can read about Kleiman's plight here, which occurred despite having what he calls "fancy-dancy health insurance through my employer, which as it happens also owns one of the world's dozen best medical centers".)

And what about that favorite of US health care apologists, the waiting time for hip replacements? Krugman looked at that too:

On the other hand, it's true that Americans get hip replacements faster than Canadians. But there's a funny thing about that example, which is used constantly as an argument for the superiority of private health insurance over a government-run system: the large majority of hip replacements in the United States are paid for by, um, Medicare.

That's right: the hip-replacement gap is actually a comparison of two government health insurance systems. American Medicare has shorter waits than Canadian Medicare (yes, that's what they call their system) because it has more lavish funding -- end of story. The alleged virtues of private insurance have nothing to do with it.

Krugman's conclusion is right on target:

The bottom line is that the opponents of universal health care appear to have run out of honest arguments. All they have left are fantasies: horror fiction about health care in other countries, and fairy tales about health care here in America.

POST SCRIPT: Déjà vu

As usual, cartoonist Tom Tomorrow succinctly captures how the media is colluding with the administration in fanning the flames for war with Iran, exactly the way it did with Iraq.

July 18, 2007

Evolution-11: The rise of population genetics and the neo-Darwinian synthesis

(Please see here for previous posts in this series.)

The joining of Darwin's theory of natural selection with the Mendelian theory of genetics is one of the great triumphs of biology, now called somewhat grandly the 'neo-Darwinian synthesis'. It forms the basis of all modern biology, and was strengthened by the discovery of DNA as the structure of genetic information and which explained how Mendelian genetics worked on a microscopic scale. The modern ability to map out the entire genome of humans and other species has produced overwhelming evidence in support of Darwin's theory of how organisms evolve and branch out into different forms. The rough tree of life that Darwin sketched out in his book based on the anatomy of biological species has now been made more precise and detailed by the mapping of the DNA of species, showing ever more clearly how species are related to one another and when they separated from a common ancestor.

Mendel showed that genes were discrete objects that retained their identity as they were handed down from generation to generation and that thus any changes in genes, however small, did not get blended away in a regression towards the mean. So you would have thought that the rediscovery and rapid popularization of Mendel's ideas in 1900 would have signaled a resurgence of Darwin's idea that natural selection worked on very small, almost continuous changes, and the defeat of those who argued that one needed discontinuous changes for evolution to occur.

Ironically, the exact opposite happened. Because Mendelian genetics was a discrete mechanism with the genetic information seeming to occur in small lumps that remained intact, it superficially seemed to support the discontinuous model of natural selection, and the proponents of discontinuous changes were able to co-opt Mendel's theory to their cause. By around 1908 or so, it seemed like Darwin's own favored model of small continuous changes leading to large changes was in almost total retreat, actually doomed by the arrival of Mendel. While there was a sprinkling of mathematicians like Udny Yule (what a wonderful name!) who argued that Mendel's theory was compatible with Darwin's model of continuous evolution, their voices were lost in the volume of controversy generated by the competing biological schools. (The Origins of Theoretical Population Genetics, William B. Provine, 2001, p. 85)

Part of the problem was that scientists were still struggling to understand the workings of both Darwin's theory and Mendelian genetics and many misunderstanding of each were then prevalent. For example, one thing that was puzzling about genetics (and puzzled me for a long time too) was this whole business of dominant and recessive genes and how it affected population distributions.

It was Mendel's work that argued for the existence of these two types of characteristics, the actual mechanism of which became better understood with the discovery on DNA and increased understanding of the way that chromosomal information was handed down from parent to child.

Simply put, each person has pairs of genes, one from each parent on the respective inherited chromosome. To be concrete, we can look at the gene for eye color. Each gene may be of a dominant type (denoted by A, for say brown eyes) or a recessive type (denoted by a, for say blue eyes). So a person would have one of the pairs AA, Aa, or aa on the pair of chromosomes that contain the genes for eye color. Since A is the dominant one, it always wins, and so those people with either AA or Aa will have the characteristic A (brown eyes) manifest itself in their features, and only the person who has aa will display the characteristic a (blue eyes). Each parent will also have AA, Aa, or aa, and will randomly pass on just one of the pair of genes it possesses to the child.

It seems intuitive that if a population starts out with some distribution of AA, Aa, and aa types, and there is random mating in the population, then the number of people displaying the dominant characteristic A will steadily increase in the population, while the manifestation of the recessive characteristic a will decrease and perhaps eventually even disappear altogether, since only someone possessing the relatively unlikely combination aa will manifest it. Since regressive characteristics did not seem to be disappearing in real life populations, and in fact seem quite stable in their numbers, early geneticists had some doubts about whether they were interpreting Mendel's model correctly.

But starting around 1908, things started to change as better experiments were done and more mathematical versions of the two theories started being used. Mendelian and Darwinian theories started to get quantified and people began to realize that Darwin's version of natural selection with continuous changes was in fact compatible with Mendel's theory. By 1918, the reversal was complete and Darwin was ascendant and has remained so ever since. This was largely due to the rise of the field now known as population genetics, whose practitioners developed mathematical models that looked at the consequences of Mendelian genetics in natural selection.

What started the shift was the result now known as the Hardy-Weinberg law, which will be discussed in the next posting in this series.

POST SCRIPT: American beliefs about evolution

Gallup has done one of its periodic surveys about Americans views on evolution

These results show that:

  • 24% of Americans believe that both the theory of evolution and the theory of creationism are probably or definitely true.
  • 41% believe that creationism is true, and that evolution is false.
  • 28% believe that evolution is true, but that creationism is false.
  • 3% either believe that both are false or have no opinion about at least one of the theories.

That first group of 24% is definitely confused, since there is no way that evolution could have occurred in the 10,000 years or less allowed by creationism. The survey creators speculate that these were people who believed that god influenced evolution and somehow wanted to incorporate that view and responded in contradictory ways depending on which question was asked.

Also:

  • The reasons for rejecting evolution were mostly religious.
  • The more regularly you attended church, the less likely you were to believe in evolution.
  • Republicans were less likely to believe evolution (30%) than Democrats (57%).

Summary:

It is apparent that many Americans simply do not like the idea that humans evolved from lower forms of life. This appears to be substantially based on a belief in the story of creation as outlined in the Bible -- that God created humans in a process that, taking the Bible literally, occurred about 10,000 years ago.

July 17, 2007

Hidden costs of US health care

(For previous posts on the topic of health care, see here.)

In my previous posts following on the film Sicko (Haven't seen the film yet? It is well worth it.) I have been focusing on the tangible costs and benefits of the US health care system compared to those of other developed countries, and showing why the US system comes out badly in comparison. The chief culprit is the insertion of profit-making private health insurance companies between the patient and health care providers, creating an immediate trade-off between profit and providing care that is detrimental to the latter.

But there are several intangibles that are also important. The main one is that having one's health insurance tied to one's place of employment highly distorts the basis on which people make important life decisions. Right now, many people make decisions of what job to take and where to live based on the health care provided by employers. People with families and young children are especially caught in a bind. Some people spend their entire lives in dead-end jobs that they hate, trapped because of the fact that they cannot afford to leave and lose the health benefits. This is especially so if they or a member of their family has a health problem that becomes a non-covered 'pre-existing condition' in their new workplace, and thus denied coverage, at least for a limited time.

What is the cost of this? For one thing, it discourages entrepreneurs and freelancers. A person who wants to quit his or her job to start their own business or implement an innovative idea is strongly discouraged from doing so, especially if they have families. Not only is the cost of purchasing private insurance for themselves prohibitive, so is the cost for providing it for their employees. In 2004, the average cost of health insurance for family coverage was $9,950, which means that it is likely to be around $12,000 in 2007. This is close to the amount earned annually by a full-time minimum wage worker. How many business ideas have never seen the light of day, how many jobs never created, because potential innovators just could not bring themselves to risk the health of their families by leaving their jobs?

Health insurance tied to businesses also discourages the creative arts. Painters, writers, sculptors, poets, actors, dancers, and musicians are people who add enormously to the quality of life of a community. A community that has a vibrant arts community is one that is lively and healthy. Most artists do not go into it for the money (although they have dreams of their work becoming widely recognized someday) but because they really love what they do and are willing to suffer some hardship for it. They are willing to forego luxuries and live fairly Spartan lives with respect to housing, food, clothing and the like, just to have the opportunity to create art. Many are willing to take part-time jobs to cover life's essentials so that they have the time and freedom to devote to their passion. But the biggest single expense for such people is the cost of buying health insurance as private individuals. Many simply do not do so, gambling that they will not get very sick.

Then we have young people, straight out of high school or college who may want to experience a carefree life for at least a short time before settling down, and maybe travel around this vast country doing various jobs, seeing new things, meeting new people, and learning about the various communities they pass through. Maybe they want to work in underprivileged areas. Right now, the only way to safely do that is to do it through an organization that provides health insurance. If they go on their own, they have to buy expensive private health insurance or take the risk that they will not need health care. Even for the volunteer organizations that provide health insurance, providing it is a big headache and expense.

Then there is the problem of transitioning between jobs and between school and jobs. There are often gaps between the times when students leave college and start their first jobs. Because they have left school, they no longer are covered by their family or school health insurance policies. They have to shop around for some coverage for the transition period until they get their first job. People who have a gap when they move from one job to another can sometimes use COBRA coverage during the transition.

Even people who like their jobs and have health insurance plans to choose from (the so called 'lucky ones') face all kinds of irritations. The family may select an insurance plan and from it choose pediatricians for their children, an internist for the parents and a gynecologist for the mother, all within that one plan. The next year, they are likely to find that some of the physicians are now on different plans. So you have to repeat the process of comparing health care plans, weighing the costs and benefits, comparing physician lists, and trying to figure out who and what to keep and to jettison. This has to be done every year. And then you have to keep track of all the paperwork and receipts and co-payments. I think people have got so beaten down that they simply do not realize how much time goes into taking care of all these details. It is only when they get drawn into the bureaucratic nightmare that results when coverage is denied or some major illness strikes that they realize what a crazy system they are in.

Why have people in the US become so numb and accepting of this state of affairs? In surveying the responses to the film Sicko, James Clay Fuller makes a good point:

Not one mentions the comments by Tony Benn, a former member of Britain's Parliament. Yet Benn's statements probably are the most profound element of the film.

He notes, as other good people often do, that "if we have the money to kill (in war), we've got the money to help people."

But, more importantly, Benn tells Moore, that all of Europe and many other places have good health care systems while the United States lacks such a basic service because in Europe and elsewhere, "the politicians are afraid of the people" when the people get angry and demand some action. In the United States, he observes, "the people are afraid of those in power" because they fear losing their jobs, fear being cut off from health care or other services if they speak up and make demands.

"How do you control people?" Benn asks, and he answers: "Through fear and debt."

His point is that in the United States we have a great overabundance of both.

When are people going to get angry enough to say "We're mad as hell and we're not going to take it anymore"?

POST SCRIPT: The invertebrate Congress

On Bill Moyers' show, Conservative Bruce Fein argues why Bush should be impeached and criticizes a spineless Congress for not doing so, and John Nichols (author of the book The Genius of Impeachment) agrees.

Here is a transcript.

Another conservative Paul Craig Roberts (Assistant Secretary of the Treasury in the Reagan administration and former Associate Editor of the Wall Street Journal editorial page and Contributing Editor of National Review) has also called for the immediate impeachment of both Bush and Cheney.

The idea of impeachment was inserted into the US constitution as a vital check against the president assuming dictatorial powers akin to those of a king. It was almost tailor-made to deal with situations like that which currently exists. But the Democratic Party leadership seems unwilling to do this.

July 16, 2007

Evolution-10: The debate over natural selection in Darwin's own time

(Please see here for previous posts in this series.)

In Darwin's own time, there was a three-way dispute concerning the theory of evolution. Strange as it may sound these days in the US where so many question whether evolution even occurs at all, the idea that evolution had occurred and new species were being created and old ones dying out was not such a major problem in the mid-to-late 19th century. Elite opinion of that time had been exposed to that idea and had accepted it even before Darwin because of all the fossil records that were being discovered all the time. Even Darwin's own grandfather Erasmus Darwin, a freethinker, had around 1795 published a book Zoonomia that had floated the idea that species had evolved, but he used a Lamarckian model. What religious people mostly shied away from was the idea that human beings were also part of the evolutionary process and shared common ancestors with other species, a reluctance that still persists.

In Darwin's time what the dispute mainly centered on was the mechanism of evolution and how it operated.

Apart from Biblical literalists and believers in special creation, there were those of a religious bent who argued that god had to intervene somehow at least occasionally to create new species (especially humans) and this view persists down to this day among people who seek a tangible role for religion. At the very least, believers in an immortal soul needed a god to insert it into humans at some point in that person's development.

But the more interesting dispute was among those scientists who were not invoking religious ideas. Their dispute centered on the scale of the mutations necessary for natural selection to work.

Due to all the buffeting that Darwin's theory had received from those who argued that the age of the Earth was too short for evolution to have occurred and that mutations would get blended away, in the later editions of his book, Darwin himself started qualifying some of the more ambitious claims that he had forthrightly stated in the 1859 edition. As a result, his later editions lost some of the directness and clarity of his first edition, and scholars now recommend reading the first edition as being the best. I personally found it a fascinating book, remarkably accessible to the layperson.

For example, his first edition contained a rough estimate by him, based on geological phenomena he observed in England, that the Earth was about 300 million years old, which was in his view sufficient time for evolution to have occurred. He arrived at this by assuming that the Weald, a valley in the south of England, had been created by erosion that had always occurred at the same rate it was occurring now. He removed this claim in later editions, presumably due to unease over physicist William Thomson's calculations that the Earth was only 30 million years old. As it turns out, Darwin had no need to be worried since the current age of the Earth is calculated to be more than ten times his own estimate.

But while willing to give ground on some peripheral issues, Darwin steadfastly stuck until his death (in 1882) to one central idea, and that was that natural selection was able to act on even extremely small advantages in the fitness of some organisms, causing them to grow in the population, and that it was the cumulative effect of these minute changes that led to new species.

Contrasted with Darwin's continuous model of change were those scientists (including even Darwin's staunch defender and ally Thomas Huxley) who argued that natural selection could not really work with very tiny changes because they would get washed away because of blending inheritance. These people argued in favor of a discontinuous model which only valued those mutations that produced significant changes in the organism that represented a new and stable phenotype whose qualities were robust enough that they would not get blended away by breeding.

To better understand the difference, compare a sphere and (say) a twenty-sided die, which is almost a sphere, both resting on a table. The sphere can be shifted by any small amount and would stay in that new position. The die on the other hand, if tilted slightly and released, would revert to its original position unless the tilt were sufficient to topple it to rest on the adjacent flat face. Then it would be stable in the new position and would resist any further shift, even back to its original state. One faction led by Darwin was arguing that natural selection could act on the continuous changes represented by the sphere while others said that only the changes beyond a certain critical amount and represented by the die were stable enough for selection to work on.

It must be emphasized that both sides supported the mechanism of natural selection for driving evolution. They simply disagreed on its ability to act on very small changes. While we may think that this was a small issue to disagree on, in actual fact the debate was fierce and very acrimonious, with both sides trying to marshal evidence for their side and picking holes in the evidence of their opponents. William B. Provine in his book The Origins of Theoretical Population Genetics (2001) gives a fascinating account of this controversy, the personalities involved, and the heated nature of the exchanges, which grew increasingly bitter by the time 1900 rolled around.

The rediscovery of Mendel's work on genetics (he was a monk who lived from 1822-1884 and published his major work in 1865, but it remained obscure until it was rediscovered in 1900) provided new fuel to the controversy. Scientists quickly recognized the significance and importance of Mendel's work. While Mendel's model was accepted as having finally produced the correct theory of how inheritance works, this did not immediately resolve the dispute because there was still disagreement about what Mendel's theory actually implied and how it fitted into Darwin's theory.

Next in this series: The synthesis of Mendelian genetics and natural selection.

POST SCRIPT: Why a secular public sphere works best

As I understand it, both US houses of Congress open with a ceremonial prayer which hardly any members bother to attend. Although each house has an official chaplain, it has become the practice to make this event more inclusive and ecumenical by having people of diverse faiths give the prayer.

For the first time last week, a Hindu was invited but his prayers were disrupted by hecklers from a Christian group, who saw this as an affront to their own god. See the video here.

Steve Benen provides some background on what happened.

Interestingly, some Christians see the saying of Hindu prayers in Congress as a sign that the end of the world is almost upon us, and their anger about this act of sacrilege is mixed with eager anticipation at seeing Jesus any day now.

One doesn't know whether to laugh or cry. I think I'll laugh.

July 13, 2007

Evolution-9: Early challenges to Darwin's theory

(Please see here for previous posts in this series.)

In an earlier post in this series, I listed the three stages involved in natural selection, each of which seemed to have seemingly small probabilities. In the previous post, I showed how because of the large numbers of organisms and long time scales involved, the first item got converted into a very high probability event.

The next item in the list, the issue of how a mutation with a small advantage in the properties of an organism can end up with that property dominating the species, was both Darwin's greatest challenge and his greatest triumph.

The triumph came from a crucial insight that Darwin had concerning the importance of varieties within species. Recall that Platonic ideas were dominant at that time, and that laid the emphasis on the idealized forms of things. So for example while a real triangle drawn on paper would contain imperfections, these were considered incidental, the drawing being a mere approximation to the idealized triangle that one could envision in some abstract space.

In Darwin's time, the biological equivalent of this thinking was that while it was plain to see that (say) chickens were different from one another in small ways, these differences were not considered important. They were considered mere approximations to an idealized chicken that represented the essence of chickenhood (so to speak), and it was the latter that was important.

But Darwin realized that the variety that he saw in species, rather than distracting from an understanding of the ideal, was important in its own right. In fact, he recognized that the diversity within a species was so vast that it was often hard to say what was a variety within a species and what was a different species altogether. As he wrote, "[I]t will be seen that I look at the term species, as one arbitrarily given for the sake of convenience to a set of individuals closely resembling each other, and that it does not essentially differ from the term variety, which is given to less distinct and more fluctuating forms" (Charles Darwin, On the Origin of Species (1859) p. 52). It was this wide variety that allowed some animals to survive better than others and was the driver of natural selection. The existence of variety lay at the heart of his theory.

(The problem with all classification schemes is that it is often impossible to specify both necessary and sufficient conditions to make unerring judgments as to which category some organism belongs. The fact that there is often no sharp line that can be drawn between varieties within species and differences between species should put to rest the artificial distinction made by intelligent design creationists who say they have no trouble with what they call 'microevolution' (what they define as change within a species) but cannot accept 'macroevolution' (the creation of new species). This is a distinction without much merit.)

But Darwin faced a serious problem. Even though people might accept his idea that one variety of an species might be more suited to survive than another, the lack of a real understanding at that time of the mechanism of inheritance worked against him. It was believed that sexual reproduction resulted in features being mixed (called 'blending inheritance'), with the child of parents being intermediate in terms of properties such as height, skin color, etc. Hence even if an occasional particular mutation had better chances for survival, it was believed that its advantageous properties would soon get diluted and disappear by mating with those animals that did not have this same property. This is the well-known phenomenon of 'regression towards the mean,' first articulated by the polymath Francis Galton, a cousin of Darwin.

In artificial breeding one could avoid this blending outcome by simply restricting the breeding of animals to those organisms with the desired properties and thus preserve and enhance desired changes. But in the wild, organisms would mate more indiscriminately and this raised the question of how advantageous mutations could be preserved.

Around the same time that Darwin's theory was already reeling from estimates of a short age of the Earth from William Thomson (aka Lord Kelvin), Fleeming Jenkins wrote a long article in 1867 criticizing Darwin's theory on precisely the blending inheritance issue. In addition, the co-discoverer of natural selection Alfred Wallace (who had initially been seen as an even more zealous advocate of natural selection than Darwin) had become interested in spiritualism and in 1869 unexpectedly published a paper in which he asserted that natural selection, although it could explain everything else, couldn't account for the human brain, and he even went so far as to espouse an early version of intelligent design creationism saying that while the living world is governed by laws, "an Overruling Intelligence has watched over the action of those laws, so directing variations and so determining their accumulation" in order to produce the wonderful thing that is the human brain (David Quammen, The Reluctant Mr. Darwin (2006), p. 215). (The idea that the workings of the human brain, and that the mind and consciousness lie outside the realm of natural selection and the laws of biology, is something that persists down to this day, a topic I will examine in the future when I look at what we are now learning about the nature of consciousness.)

There was nothing much that Darwin could do about Thomson's criticism but hope that someone else would prove the physicist wrong, which did happen with the discovery of radioactivity in the first decade of the 1900s. There was also nothing that Darwin could do about Wallace going against one of the fundamental precepts of natural selection, although Darwin felt that the whole idea of natural selection was meaningless if an outside 'intelligence' could drive organisms towards a pre-ordained result. Darwin simply wrote "No!!!" in the margins of Wallace's paper.

As for Jenkins's criticisms, Darwin had not been unaware that this would be a problem for his theory and had tried to anticipate it by suggesting that successful mutations would take hold in only those cases where the mutations appeared concurrently in numerous individuals and that these would then breed with each other, allowing that variety to grow and take root in the population. (Quammen p. 212)

Darwin's defense was not very persuasive but it was all he had. Although the real defense against Jenkins's critique was already at hand in the form of Mendel's theory of genetics (which showed that genes are discrete entities that remain intact on breeding and do not get blended away), Mendel's work was not widely known at that time and Darwin's theory had to wait until its rediscovery in 1900 to fully overcome objections of the type put forward by Jenkins.

Darwin the man and the scientist are fascinating character studies. He was painstakingly thorough in his work and conscientious about the need to amass evidence to buttress the main argument he was making. But once he felt convinced by the evidence that the theory of natural selection was sound, he was determined. While he was willing to give ground on the periphery of his theory, he was firm in his commitment to its core ideas, and one of these was that his theory would make no sense if you allowed an outside agency (an 'intelligence' or whatever name you gave to a god-like power) to intervene in the process at any time in any way. He was a methodological naturalist, a necessary condition for any good scientist.

But it is a very thin line that separates methodological naturalism from philosophical naturalism (or atheism) and this, at heart, which is why Darwin's theory is so subversive to beliefs about god.

Next in this series: The debate over natural selection in Darwin's own time

POST SCRIPT: Science? Evidence? Who cares?

In congressional testimony this week, outgoing US Surgeon-General Richard Carmona spoke of how in the Bush administration, ideology trumped science every time, with constant political interference muzzling him on scientific issues like embryonic stem cell research. He said, "Anything that doesn't fit into the political appointees' ideological, theological or political agenda is ignored, marginalized or simply buried."

His testimony reminded me of this Tom Tomorrow cartoon from February 27, 2007.

Meanwhile, Secretary of Homeland Security Michael Chertoff's extraordinary statement, also this week, that he felt 'in his gut' that a terrorist attack might occur in the US this summer reminded me of astronomer Carl Sagan's reply when an interviewer pressed him for his 'gut feeling' as to whether there was life elsewhere in the universe. Sagan replied, "But I try not to think with my gut. Really, it's okay to reserve judgment until the evidence is in." (Richard Dawkins, The God Delusion, p. 47.)

Chertoff would be well-advised to follow Sagan's advice.

July 12, 2007

How universal single-payer systems protect us against catastrophes

(For previous posts on the topic of health care, see here.)

I think almost everyone across the political spectrum would concede the fact that the fifty million Americans currently without health insurance would definitely benefit from the adoption of a universal, government-run, single-payer health care system. The reason that it has not been adopted is that many of the remaining 250 million have been frightened into thinking that their medical coverage would decline from what they have now.

This feeling that "The present system works for me so why tinker with it?" is based on the assumption that our lives are stable and that things will continue just as they are into the foreseeable future. I am not so sanguine about this, perhaps because I am older and have repeatedly seen and experienced how the slings and arrows of outrageous fortune can strike anyone at any time and dramatically change lives. As a result I think it unwise to base our policy decisions on the rosy assumption that what is true for me now will continue to be true for me tomorrow. All it takes is a single catastrophe that causes the loss of our job, which could happen to any of us at any time, and all our comfortable assumptions about the future can end up in the trash can.

It is not uncommon for people who are incapacitated by an illness or an accident to themselves or someone in their family to lose their jobs and not be able to get another one with health benefits. As a result, such families are faced with stark choices: suffer or die for lack or treatment or have the family risk bankruptcy paying for it.

US News & World Report summarized the findings of a study that looked at a representative sample of bankruptcies across the country:

We have health insurance for several reasons, but one of the big ones is to protect us from high medical bills when we get sick. But insurance, it turns out, may not be the protection that many people think it is. Illness and medical bills are big reasons behind fully half of all personal bankruptcies, affecting about 700,000 households per year, according to a new study. And most of those households had insurance.
. . .
These were working- class or middle-class people, and 76 percent of them had health insurance when they first got sick. (Many lost this coverage because the insurance was through their jobs, so it disappeared when they couldn't work.) Half of the bankruptcies were caused, in part, by illness and medical debt. Their median debt was about $16,500, and the major part of that debt was payments to doctors and hospitals. Families initially tried to pay the debt for several months, says Elizabeth Warren, a bankruptcy expert at Harvard Law School. Sixty-one percent went without needed medical care to make payments, 30 percent had a utility shut off, and 22 percent cut back on their food.

If you simply ask around, you will find many examples of people who have been forced to make drastic decisions because of their health care situation. A couple I know moved to Mexico because they could not afford to pay for their health care here.

But even if people are willing to shut out from their minds the possible of such an unfortunate turn of events happening to them personally (and human beings are very skilled at avoiding thinking about such things), surely they would like to feel that their families and children and grandchildren and great-grandchildren will not have to suffer? The odds are very high that several people in each one of our extended families will face a health-related crisis in their lives that will threaten to send them into destitution. Even if we are blasé about ill health striking total strangers, surely we cannot be so complacent about our own descendents?

David U. Himmelstein, MD and Steffie Woolhandler, MD provide a detailed case (scroll down) for "Why the US Needs a Single-Payer Health System" outlining the toll the present system in the US takes on both patients and health care professionals, and the increasing monopolization of the system by a few giant corporations. They describe the huge amounts of paperwork that doctors in the US have to do because of the complicated and cumbersome health insurance system here. They have to employ a number of clerical staff simply to process the different paperwork with all the different insurance companies and then haggle with them over payment and treatment. In addition, the health insurance companies have to negotiate contracts with different companies in different states with different laws and regulations. As a result, "Blue Cross in Massachusetts employs more people to administer coverage for about 2.5 million New Englanders than are employed in all of Canada to administer single payer coverage for 27 million Canadians."

Perhaps we should start by providing single payer health care coverage to all children. Children are not responsible for their lot in society and should not be deprived of basic needs of food or shelter or clothing or education or health care.

There was a very sad story in the film Sicko. (Although I keep talking about the sad stories in it, I should emphasize that Sicko is also a very funny film.) It was about a little girl who was taken to a hospital emergency room with very high fever. They refused to provide treatment because she was not 'entitled' to be treated there, and insisted that she be transferred to a hospital across town, the place where she was 'supposed' to go to. She died during the time that she was transferred from one hospital emergency room to another.

To be denied treatment for purely bureaucratic reasons is unconscionable. It puts the health care professionals also in an impossible situation. If the emergency room physicians and nurses at the first hospital had realized that the child had a life-threatening condition, I am certain that their natural humanity would have taken over and they would have treated the child irrespective of whether she qualified or no