Research Associate position available in the laboratory of Michael E Harris, PhD at Case Western Reserve University in Cleveland, Ohio. Projects involve the study of RNA-metal ion interactions using solution Raman spectroscopy. The principle RNA systems utilized in the laboratory include small and large ribozymes and structural motifs derived from functional RNAs. Projects will entail determination of the thermodynamics of RNA-metal ion interactions in the aforementioned systems using both a range of biophysical and spectroscopic tools in conjunction with novel methods for the Raman spectra of RNAs in solution. The ideal research associate candidate should be highly motivated, have a PhD or MD degree, a strong background in molecular biology, enzymology, stopped flow and equilibrium spectrometry and publications in internationally recognized journals. Applicants should be fluent in English and be available for an interview. Experience with nucleic acids and biophysical or chemical kinetic approaches is preferred. Please send a cover letter, brief description of research experience and interests, curriculum vitae and contact information for three references via email to Michael E Harris, PhD., email address: meh2@case.edu For more information, please visit: http://www.case.edu/med/biochemistry/ Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Center for Clinical Investigation (CCI), Medicine Responsible for developing and managing multi-institutional Clinical and Translational Science Collaborative (CTSC)-wide clinical, biomedical and administrative informatics projects focusing on meeting project timelines and deliverables; interfacing with key stakeholders such as faculty, CTSC staff and investigators, and CTSC cores; coordinating project activities with the University Vice President for Information Technology Services/CIO, and IT directors of the School of Medicine and Case School of Engineering; interact with the national CTSA consortium through its Informatics Key Function Committee (IKFC), NCRR, and NIH. Position will spend majority of time managing multiple informatics systems projects through specification, development, adoption, testing, deployment, continued enhancement and system integration responsibilities, with an emphasis on end-user experience. The position will critically involve high-level decision-making and leadership in the planning, and implementation of complex technical projects. Projects to include establishment of web portals, tracking systems, data collection, project reporting, database design and maintenance, data management systems integration across CTSC member institutions, informatics, statistical and IT support for CTSC investigators, and establishment of new translational, comparative effective technologies and methodologies. ESSENTIAL FUNCTIONS • Develop and implement informatics architecture and projects for CTSC translational research. Prepare project plans and status reports. • Provide and manage shared IT and informatics resources, tools, systems, underlying connectivity and security to support the CTSC administrative “home†at the Center for Clinical Investigation. • Develop data integration and reporting capabilities across informatics systems and tools. • Assess the needs for computer hardware and software environments. Develop policy and protocols for implementation, programming and/or maintenance of major software systems. • Establish and enforces software development life-cycle best practices, particularly Agile methodology using tools such as Rally. • Manage technical resources within budget and project schedule. • Serve as a member of Biomedical Research Informatics Management (BRIM) executive team member and collaboratively develop implementation plans under the directive of the BRIM co-directors, CRU leadership, and the CTSC PIs. • Attend regular status meetings as an executive member of the BRIM team with responsibilities for managing IT and informatics systems. • Research and demo existing research IT and informatics tools or expertise across CTSC locally and the IKFC and CTSA consortium nationally. • Support investigators with grant, scientific or IRB submissions for research data management needs. • Help simplify and standardize intra-and inter-institutional research policy and processes. • Attend regional and/or national meetings as needed. NON-ESSENTIAL FUNCTIONS • Identify training and educational resources, in the School of Medicine, Cleveland Clinic, MetroHealth, and University Hospitals of Cleveland • Attend university and SOM training sessions to keep up to date with policies and procedures. • Perform other duties as assigned. REQUIREMENTS AND QUALIFICATIONS Experience: 6 years developmental experience in software life-cycle, including programming as well as management and project management experience; experience in Agile project management using tools such as Rally. Experience in project management methodologies and advanced technical skills. High level of communication skills and an aptitude for collaboration. Prior experience in an academic and/or industrial research development setting desired. Education/licensing: PhD degree preferred, preferably in computer science, healthcare informatics, or related field OR MSc with 6 years experience. Prefer additional background/experience in clinical and medical research. Essential skills: 1. Strong organizational, computing, and communication skills required. 2. Basic understanding of how technology aligns to business strategies and initiatives. 3. Deep understanding of web-based application tool development and agile development framework. 4. Must have initiative, flexibility, self-confidence, high ethics and values, and embrace diversity. 5. Must have good leadership and facilitation skills. 6. Must be able to translate high-level directives to implementable systems 7. Knowledge of business processes, and healthcare IT and/or clinical research informatics. 8. Ability to work constructively with senior institutional and multi-institutional personnel in IT. 9. Ability to actively learn and understand the implications of new developments in informatics for both current and future problem-solving and decision making. 10. Ability to easily recognize system deficiencies and implement effective solutions 11. A history of consistently delivering high-quality services. 12. Must be able to deliver engaging, informative, well-organized presentations. 13. Must be able to resolve and/or escalate issues in a timely fashion. 14. Must understand how to communicate difficult/sensitive information tactfully. 15. Must be a team player. 16. Must be dedicated to his/her team and give full attention to his/her role. 17. Must have the attitude of being dedicated to his/her position and give full attention to critical jobs until completed. 18. Ability to build an initial project plan for small to large size complexity for multi-institutional projects, based on collaboratively established requirements. Technical skills 1. Ability to review technical design documents to ensure requirements are met. Ability to create technical documentation and understand the fundamentals of software and/or system development life cycles. 2. Must understand project management software tool usage, e.g. Rally. 3. Knowledge of joint or rapid application development methodologies including Agile or Extreme Programming for rapid prototyping. 4. Must possess extensive experience in web-based application development, using the MVC paradigm, in Ruby-on-Rails. Developmental experience in GWT preferred. 5. Knowledge and understanding of various clinical research informatics systems: 1) electronic medical record systems (Epic at Cleveland Clinic and MetroHealth); 2) clinical trial management systems (Velos and Oncore); 3) various biospecimen repository applications; 4) cancer research environment and the comprehensive cancer center; and 5) clinical informatics and translational bioinformatics; 6) social networking tools. 6. Must understand computer networks, network security, client/server architectures and service-oriented architecture. 7. Must understand semantic web and biomedical ontologies. WORKING CONDITIONS Friendly and supportive team culture in a university setting. University education missions sometimes require working longer than 8-hour days. No known hazards. Please send a CV, cover letter with brief description of research experiences and interests to GQ Zhang at: guo-qiang.zhang@case.edu. Have three references available upon request. DIVERSITY STATEMENT In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. REASONABLE ACCOMMODATIONS Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Department of Neuroscience A post-doctoral position is available to work with Dr. Robert Miller and Dr. Yan Yang in the Department of Neuroscience/Neurology at Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA. The postdoctoral scholar will work on in vitro and in vivo models of regulation of oligodendrocyte lineage development, myelin formation and remyelination. The ideal post-doctoral candidate will be creative and highly motivated, have a PhD or MD/PhD degree with a strong background in developmental and genetic neuroscience and signaling pathway. The candidate must be able to work independently and as part of a team. The individual must have experience in primary cell culture, biochemical assay, molecular biology, DNA transfection and gene silencing approaches (siRNA, shRNA) and realtime PCR. The candidate must have working expertise with rodent animals and PCR genotyping. Applicants will be involved in writing manuscripts and scientific presentation. Please send a CV, cover letter with brief description of research experiences and interests to: yxy33@case.edu. Have three references available upon request. DIVERSITY STATEMENT In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. REASONABLE ACCOMMODATIONS Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Department of Biomedical Engineering, Case Western Reserve University Schools of Engineering and Medicine We are seeking 2-3 postdoctoral imaging researchers to develop new translational applications in cardiovascular imaging. Successful applicants will join our team of biomedical engineers, computer scientists, cardiologists, and industrial researchers. One project will advance CT imaging to include reliable perfusion measurements of myocardial tissue using the latest Philips Healthcare CT imaging technology. This advancement will allow CT to become the only imaging modality providing a “one stop shop†including vascular anatomy, vessel wall staging, and tissue perfusion. This will be exceedingly important for managing acute patients in a timely, cost effective, and reliable manner. Other positions involve optical coherence tomography (OCT) imaging of coronary arteries. OCT provides microscopic imaging of the blood vessel wall enabling unique assessment of plaque vulnerability. It also enables assessment of stent tissue coverage, unique information for the 100s of thousands of stent implantations done yearly in the US. We are seeking persons to develop new image analysis applications which can be translated to clinical solutions. Our group has a broad base of funding from the Philips Healthcare Global Advanced Imaging Innovation Center at Case Western Reserve University and University Hospitals of Cleveland, Ohio Third Frontier, Cardiovascular Imaging Core Lab, Coulter Foundation, and NIH. Applicants are expected to have a PhD in engineering or related field and knowledge of medical imaging and image analysis. Specific knowledge of OCT, CT, perfusion, and/or cardiac imaging is a plus. However, we will consider outstanding individuals with no previous biomedical imaging experience but publications demonstrating knowledge of image analysis methods. A unique aspect of our work will be accurate validation using large animal models of coronary artery disease, providing ample opportunity for publications. We want a candidate who will communicate well with our diverse, dynamic group; aggressively pursue research; and publish at a high rate. Applicants should send an email stating why they should be selected, curriculum vitae, and contact information for at least three references to Dr. Wilson at: david.wilson@case.edu. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Case Western Reserve University Department of Medicine, Division of Gastroenterology and Liver Disease Research Scholar position in mechanisms of hepatic fibrosis. Our lab group seeks a creative, energetic MD, PhD or MD/PhD with a background in basic biology, immunology or molecular biology to join a vibrant research team interested in defining mechanisms which contribute to hepatic fibrosis. The ultimate goal of this grant-funded project is to elucidate how inflammation and innate immunity contributes to fibrogenesis and identify new therapeutic targets to slow, halt and/or reverse fibrosis. Candidates should have a strong background in research using animal models (mouse preferred), in primary cells and cell line culture systems as well as have laboratory bench experience including, but not limited to immunoblotting, immunohistochemistry, histology, RNA isolation, real time PCR, flow cytometry and transfection technologies. The ideal candidate should also have excellent written and oral communication skills in English as well as a proven track-record of publication success. Successful applicants are encouraged to develop projects falling within the scope of our overall research goals and will receive considerable career development training and mentorship. Applicants should submit a letter of motivation, statement of research interests, their CV, 2 letters of recommendation and a copy of their degree via e-mail to: michele.pritchard@case.edu or mtp11@case.edu Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Reasonable Accommodations Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

The Department of Pathology at Case Western Reserve University School of Medicine The Department of Pathology at Case Western Reserve University School of Medicine has a Research Associate position available in the areas of biological, biophysical and translational aspects of human prion diseases. Successful candidates will have 0-3 years experience. The Lab and Center has developed many powerful tools to elucidate the mechanisms of replication and propagation of prions that lead to the discovery of new prion forms and diseases. Those with a strong background in prion research, protein misfolding, neurodegenerative diseases, protein-protein or protein-lipid interactions, or proteomics are especially encouraged to apply. The successful candidate will develop and validate novel physicochemical methods for the detection and conformational studies of prions in a variety of human and animal tissues, and in laboratory-generated samples. This development involves: selection, characterization, and labeling of new high-affinity prion ligands, purification of prions, florescence and circular dichroism spectroscopy, mass spectroscopy, and ultracentrifugation. Incumbent will also perform data collection, analysis of results, and writing the papers. Applicants should submit a curriculum vitae, a brief statement of research interests, and arrange for at least three letters of reference to natale.e.grabowski@case.edu Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Molecular Radiation Biology; Case Western Reserve University School of Medicine. The Department of Radiation Oncology of Case Western Reserve University School of Medicine is urgently looking for three postdoc fellows to join Dr. Junran Zhang’s group. The main interest of Dr. Zhang’s lab is to understand how the repair of DNA double strand breaks (DSB) protects against carcinogenesis and how the disrupted DSB repair contributes to sensitivity of cancer cells to radiotherapy and chemotherapy. The DNA damage response proteins which Dr. Zhang’s group is interested are BRCA1, RPA, RAD51, ATR, 53BP1, BLM and others. In addition to investigating DNA DSB response pathways, Dr.Zhang lab recently started a new avenue of investigation into the relationship of NEDD4-1 and AKT in basic cell signaling. Therefore, understanding the molecular mechanism by which NEDD4-1 activtes AKT and its implication for cancer therapy is the other focus in Dr.Zhang’s lab. The candiates are requried with a PhD degree in cancer/cell/molecular biology, biochemistry or related field and with a sound & demonstrated expertise in tissue culture, protein biochemistry & molecular biology technique and immunofluorescence microscopy. The candiates with experience of mouse work is also encourged to apply. Effective verbal and written communication skills will be required. Annual salary will be determined depending on qualifications and experience. If interested, please send a cover letter and a CV via email to: Junran.zhang@case.edu Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Department of Molecular Biology and Microbiology Case Western Reserve University School of Medicine The Department of Molecular Biology and Microbiology at CWRU School of Medicine is continuing its expansion under our Chair, Dr. Jonathan Karn. We are currently seeking applications for Associate/Full Professor level positions. We encourage applications from highly qualified individuals with demonstrated experience in the areas of: • Molecular Virology. Fundamental aspects of Virology (e.g. molecular mechanisms in viral replication; virus assembly and maturation; control of latency; host cell interactions; virus entry mechanisms; viral diversity and immune evasion). • Cancer Virology. Basic virology leading to a fundamental understanding of the molecular basis for tumorigenesis. This includes interests in the discovery of new human pathogens, viral etiology of cancer, viral models for cancer. Successful candidates will establish a vigorous research program, participate in teaching activities, and interact productively with a nationally-ranked team of basic and clinical scientists interested in the overall areas of HIV/AIDS and host-pathogen interactions, microbiology and infectious diseases. We stress excellence in research and in teaching. • Candidates at the Full Professor level should have a Ph.D., an outstanding record of scholarly achievement and record of leadership and service at the national or international level in the profession, and a record of sustained Federal funding. • Candidates at the Associate Professor level should have a Ph.D., a substantial publication record and an established reputation for professional excellence, and a record of sustained Federal funding. In addition to newly refurbished laboratory space and a generous start-up package, we offer a highly interactive environment with exceptional intellectual, infrastructural, and administrative support. All candidates should have a Ph.D. and relevant post-doctoral experience, and a record of funding, active research program and a national reputation. Rank and salary will be commensurate with experience. Please submit an online application including a letter of application, curriculum vitae, brief statement of research goals and accomplishments, and 3 references as PDF files to: Jonathan Karn, Ph.D., Chair; Virology Search Committee at: http://sunshine.case.edu/mvcvsearch/index.htm. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

The Department of Nutrition of the Case Western Reserve University School of Medicine seeks an established investigator focusing on the metabolism of brain, heart, liver or beta cells, in health and disease. We seek an expert in the use of stable isotope technology and metabolomics who will be part of the core leadership of our new Metabolomics Center. This is an Associate Professor/Professor, tenured/tenure-track position. Appointment at the level of Associate Professor will require evidence of progress toward a national reputation for research expertise, a distinguished record of publication, and a record of funded research. Appointment at the level of professor will additionally require a significant national reputation for research excellence. A substantial start-up package comes with the position. Please send curriculum vitae, summary of research accomplishments and outline of future research directions to Dr Henri Brunengraber at henri.brunengraber@case.edu, or mail to the Department of Nutrition, 10900 Euclid Avenue, Cleveland, OH 44106-4954. In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Pharmacology, School of Medicine, Wood Building, 3rd Floor POSITION OBJECTIVE: This position within Department of Pharmacology is for a highly motivated individual with good communication skills and ability to interact with an interdisciplinary group ranging from biochemists to crystallographers. The responsibilities include: planning and executing between 4-6 projects in collaboration with faculty members at CWRU. The TBN SRA will contribute to develop the experimental design for the collaborative projects, which include membrane protein expression and purification, as well as high-throughput and high-resolution approaches to structure determination of membrane proteins using cryo-electron microscopy and 2D crystals. He/she will perform cloning and expression experiments, protein purification, and crystallization series. The qualified candidate will also participate in the development of new 2D crystallization methods, software, and 3D crystallization of transporters and receptors. As a SRA he/she will prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals. He/she will develop and present seminars on crystallography research methods and scientific findings. He/she will collaborate with members of the Pharmacology Department to develop training programs in membrane structural biology. The SRA will conduct research for a variety of biological and clinical problems based upon the interests of the collaborating PIs. ESSENTIAL FUNCTIONS 1. Contribute to developing the experimental design for collaborative projects that involve membrane protein expression, purification and crystallization. 2. Perform cloning experiments, protein purification, EM data acquisition. 3. Participate in development of 2D and 3D crystallization methods 4. Preparation of manuscripts and contribute to obtaining preliminary data. 5. Attend seminars in/out of the department. 6. Participate in training programs in membrane structural biology NONESSENTIAL FUNCTIONS 1. Perform other duties as assigned. CONTACTS This section is important in rating the position, so please give it thought and consideration when developing the position description. Indicate who the incumbent will have contact with (i.e., department staff, students, potential donors), the frequency (i.e., infrequent (up to 5%), occasional (6-15%), moderate (16-30%), regular (31-45%), frequent (46-65%), and continuous (66+%) and for what purpose (i.e., provide information, resolve complaints, solicit donations). Department: Faculty, Staff, (85%, University: 0%, External: 2-5%, Students: 10%+ depending on how many students are recruited SUPERVISORY RESPONSIBILITY The candidate will supervise a Laboratory Research Assistant, postdoctoral scholars, graduate students and undergraduate students in conducting sample preparation, experimental design and data analysis of a variety of projects within CWRU and TEMIMPS QUALIFICATIONS PhD in structural biology (x-ray crystallography) 8-10 years experience in high-resolution structure determination, protein expression and methods development. REQUIRED SKILLS Strong expertise in membrane protein handling and high-resolution structure determination, as well as proficiency in writing scientific reports and papers is required WORKING CONDITIONS Ability to work in a diverse environment. Will require travel between CWRU main campus and CCMSB on a regular basis. Ability to lift 15 lbs, well versed with computers. Interested individuals should submit a curriculum vitae, and a brief statement of research interests and career goals to Krzysztof Palczewski, Ph.D. at: krzysztof.palczewski@case.edu Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Reasonable Accommodations Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

The Department of Modern Languages and Literatures invites applications for an Assistant Professor tenure-track position in Chinese, to start in the fall of 2012. All applicants must have PhD (by time of appointment) in Chinese with an educational and research background in Chinese language and literature, and show evidence of ability to carry out a research program consistent with the expectations of a research university. Additionally, they should have native or near-native fluency in Chinese and English. Applicants should have a strong commitment to teaching excellence and interdisciplinary learning, and should be willing to teach Chinese language and literature courses at all levels. Interest in/experience in multi-media pedagogy is welcome. Normal teaching load is 2/3. The successful candidate will lead the expansion of the program in Chinese in collaboration with the university’s interdisciplinary programs and initiatives at the local, national and international level. Please send application materials (cover letter, C.V., and three confidential letters of recommendation sent independently by the references) electronically to: antonio.candau@case.edu, or by U.S. mail by January 18, 2011to: Chinese Search Committee, c/o Antonio Candau, Department of Modern Languages and Literatures, CWRU, 10900 Euclid Avenue, Cleveland, OH, 44106-7118. In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Case Western Reserve University, School of Medicine, Division of Infectious Diseases Research HIV vaccine development by using intersubtype recombinants. Characterize the HIV virus. Construct plasmid clones of HIV with yeast recombination. Study HIV neutralizing antibodies. Position requires an M.D. and/or Ph.D. in Virology, Immunology, or Biology. Must have research experience involving molecular virology/immunology, gene expression in mammalian cells, utilization of small animal models. Send resume and salary requirements to: Dr. Yong Gao, CWRU, Division of Infectious Diseases, BRB 1010, 2109 Adelbert Rd., Cleveland, OH 44106-4984. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Reasonable Accommodations Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Research Associate position in The Department of Epidemiology and Biostatistics at Case Western Reserve University The Department of Epidemiology and Biostatistics at Case Western Reserve University School of Medicine has an opening for a Research Associate. This position is currently half time, though opportunities to expand to full time are possible. Candidates should have a doctorate degree in Biostatistics, Statistics, or related field. The person in this position will provide support to methodological and data analysis projects involving mediation analysis and other causal inference methods, in the context of behavioral/social environmental health research. Duties will include programming in R and SAS for data analyses and simulation studies, as well as assistance in the development of R packages. The position will also involve participation in writing of statistical methodological papers for publication. The successful candidate will have 1) expertise and experience in SAS and R programming, 2) strong math and statistical computing background, 3) interest in learning and developing new statistical methods (particularly in causal inference), 4) interest in behavior research in health areas (such as dental and cancer research), 5) excellent oral and written communication skills. Interested individuals should submit a curriculum vitae, and a brief statement of research interests and career goals to Jeffrey M Albert, PhD at jma13@case.edu. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Reasonable Accommodations Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Postdoctoral scholar in Epidemiology and Infection Control of Clostridium difficile A Post-doctoral scholar position is available in a laboratory at the Cleveland VA Medical Center, Case Western Reserve University in Cleveland, Ohio, USA. The postdoctoral scholar will coordinate the laboratory component of a 3-year study involving development and implementation of an environmental disinfection intervention to control Clostridium difficile. Projects will involve epidemiology of C. difficile, molecular typing, and evaluation of infection control interventions. The ideal post-doctoral scholar candidate will be creative, highly motivated, have a PhD degree or MD/PhD degrees, and a strong background in microbiology and molecular epidemiology. Applicants can speak and write English, are familiar with Microsoft office, and have a strong ability to learn new techniques. The candidate must be able to work independently and as part of a team. This individual must have experience in microbiology including culture and susceptibility testing of anaerobic bacteria, DNA extraction, and PCR. Please send a cover letter, brief description of research experience and interests, curriculum vitae and contact information for at least three references to Curtis.Donskey@va.gov. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Case Western Reserve University School of Medicine and University Hospitals Case Medical Center is seeking an exceptional candidate to serve as the inaugural Director of the newly founded Respiratory Health Institute; Chief, Division of Pulmonary and Critical Care Medicine; and the Hubbell Chair and Professor of Medicine. The incumbent is responsible for developing a vision and strategic plan for clinical, research, and educational activities of a new Institute and service-line dedicated to respiratory and thoracic disease, including asthma and chronic obstructive pulmonary disease, pulmonary hypertension, sleep medicine, lung transplantation, pulmonary rehabilitation, critical care, and thoracic surgery. University Hospitals Case Medical Center is the primary teaching affiliate and academic medical center for the University Hospitals Health System, a top 10-rated (Thomson Reuters) integrated health network in Northeast Ohio with five wholly-owned community medical centers, seven ambulatory health centers, and a network of greater than 400 primary care physicians. Case Western Reserve University School of Medicine is noted for strong basic science departments committed to premier fundamental discovery science, and is currently ranked 13th in extramural support from the National Institutes of Health. The Division has a long and distinguished tradition of excellence in research, clinical practice, and education, recognized as a leading Division in Respiratory Care by US News and World Report. The Division currently has 18 full time faculty with eight NIH-funded investigators, an annual NIH grant portfolio over $4 million plus significant research funding from other sources. The research programs are housed in a state-of-the-art biomedical research building. CWRU has outstanding biomedical research programs with collaborative opportunities including expanding scientific initiatives in cancer, cardiovascular and digestive diseases, and neuroscience. The Division’s educational mission encompasses two hospitals, University Hospitals Case Medical Center and Louis Stokes Veterans Affairs Medical Center, with eight fellows through a Pulmonary/Critical Care fellowship program, Sleep Medicine fellowship, and a NIH-funded training grant capable of supporting pre- and post-doctoral candidates. The successful candidate will have an outstanding record of scholarly achievements, sustained extramural research funding, along with proven leadership, mentoring and administrative abilities. He/she should qualify for the rank of Professor with tenure at CWRU. A strong commitment to leading the Institute and Division in national prominence through building inter-disciplinary programs is expected. Candidates should submit their curriculum vitae and a letter describing their research, teaching, service and administrative experience to: Daniel I. Simon, MD, Chief Division of Cardiovascular Medicine, Director, University Hospitals Harrington-McLaughlin Heart & Vascular Institute and Chair of the Search Committee, 11100 Euclid Avenue, Lakeside Hospital Suite #3001, Cleveland, Ohio, 44106-5038. E-mail: daniel.simon@uhhospitals.org In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at (216) 368-8877 to request a reasonable accommodation. Determination as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

In the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine A unique translational cancer research opportunity is available to work with Dr. Kishore Guda and Dr. Sanford Markowitz at the Case Western Reserve (CWRU) Comprehensive Cancer Center in the area of Barrett’s esophagus and associated malignancies. The motivated research associate will be working in close collaboration with a multi-investigator team consisting of clinicians and basic scientists within the CWRU GI Specialized Program of Research Excellence (SPORE) and Barrett’s esophagus Translational Research Network (BETRNet), and will be an integral member of the cancer genetics program at CWRU comprehensive cancer center. Specifically, the candidate will be working towards a) identifying the genetic cause of Familial Barrett’s neoplasia, and b) identifying novel coding and non-coding RNA biomarkers of cancer risk in Barrett’s esophagus patients by employing cutting-edge techniques such as nextgeneration sequencing. The candidate will also be responsible for designing and executing functional assays using in vitro and in vivo model systems, and will be involved in writing manuscripts for peer-reviewed journals, preparing posters and slides for oral presentations at various meetings, and providing assistance with writing grant proposals. Candidate must have a strong fundamental knowledge in cancer biology/genetics, and expertise with basic mammalian cell culture techniques, including cell growth assays, DNA transfection and gene silencing approaches (siRNA, shRNA). Candidate must have working expertise with bacterial transformation, nucleic acid isolation, realtime PCR, Sanger sequencing, Western blot, and immunoprecipitation. Knowledge of next generation sequencing and working with animal models will be an added advantage. Candidate should have a basic knowledge of bioinformatics and commonly used statistical tests. Candidate must have excellent oral and written communication skills. Qualified applicants should hold a doctoral degree in biomedical sciences (Cell Biology, Biochemistry, Molecular Biology, Pharmacology or Biotechnology). Applicants should submit curriculum vitae, a brief statement of research interests, and a letter of reference from primary mentor to krishna.guda@case.edu. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Two Postdoctoral Scholar/Research Associate/Senior Research Associate positions are available to study biochemical mechanisms that mediate innate immunity to HIV infection. The ongoing projects focus on cellular factors that restrict HIV infection in monocyte-derived cell lineages, and viral proteins that overcome these restrictions. The main responsibilities of these positions include: planning and executing projects in the above areas. Additional duties as a Research Associate/Senior Research Associate will include contributing preliminary data design for grant proposals as well as scientific publications. For recent publications see Srivastava et al. PLoS Pathog. 4, e1000059; Hrecka et al. PNAS 104, 11778; Hrecka et al. Nature 474, 658. All candidates are expected to have a PhD in Molecular Virology, Biochemistry or Genetics; multiple publications in internationally recognized journals, and experience in molecular biology, biochemistry or molecular virology. These positions involve extensive use of lentiviral/retroviral vectors, flow cytometry, real time PCR, and RNA interference. Priority will be given to applicants with prior experience with experimental systems of interest. The position of Postdoctoral Scholar is open to candidates with 0-2 years of postdoctoral experience. The Research Associate position is open to candidates with 2 to 4 years of postdoctoral experience. The position of Senior Research Associate is open to candidates with 5 or more years of postdoctoral experience. Salary and benefits are in keeping with NIH scales. Qualified applicants should submit a cover letter, current CV, and names and contact information for three referees to: jacek.skowronski@case.edu . Only complete applications will be considered. Diversity Statement In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Mucosal Immunology Department A Post-doctoral and a technician positions are available in a laboratory at Dental School, Case Western Reserve University in Cleveland, Ohio, USA. These positions will study lymphocyte biology, vaccine responsiveness, gut permeability, oral biology and gender related immunology in animals and human. Projects will involve immunology, molecular and cellular biology, proteomics, mouse or rabbit models, human healthy control samples and HIV-infected patient samples in studies of basic immunology and disease pathogenesis. The ideal post-doctoral candidate will be creative, highly motivated, have a PhD degree or MD/PhD degrees, and a strong background in the function of gut intestinal tract and mucosal immunology using animal models, or gender related research and proteomics. Applicants can speak and write English, are familiar with Microsoft office, and strong ability to learn new technique. The candidate must be able to work independently and as part of a team. This individual must have experience in cell culture, RNA extraction, real-time PCR and gene expression analysis. Please send a cover letter, brief description of research experience and interests, curriculum vitae and contact information for at least three references to jxw103@case.edu . DIVERSITY STATEMENT In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

CASE WESTERN RESERVE UNIVERSITY SCHOOL OF LAW invites applications for the position of Assistant Director of the Academic and Writing Support Program and Writing Center beginning in the 2012-2013 academic year. The individual will also have the faculty rank of Instructor. Depending on experience and qualifications, the initial contract will be for a period ranging from one to five years. This faculty member will have the following responsibilities, along with the program’s Director: 1) staff and supervise the Legal Writing Center; 2) provide workshop instruction and individual tutoring to students in need of academic support; and 3) design and present courses and supplementary instruction in bar-exam preparation. Candidates should have experience in academic support work and bar exam preparation. Minimum academic requirement: JD or equivalent from a US or foreign law school. In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis. Contact: Catherine Adkins, Case Western Reserve University School of Law, 11075 East Boulevard, Cleveland, Ohio 44106, (216) 368-2108, cca22@case.edu. Further information about the law school is available at http://law.case.edu.

The Neurological Institute of University Hospitals Case Medical Center at Case Western Reserve University School of Medicine is recruiting a neurologist with sub-specialization in the diagnosis and treatment of autonomic disorders. Responsibilities include leadership of the autonomic program and laboratories as well as participating in the clinical, education and research activities of the autonomic program and neuromuscular center. Additional applicant expertise and interest in neuromuscular disorders, electrodiagnosis, skin biopsy and nerve/muscle biopsy are welcomed. The ideal candidate should have completed a residency in Neurology and a fellowship in autonomic disorders and/or neuromuscular Medicine and/or clinical neurophysiology. Candidates should be board eligible/certified in neurology and in neuromuscular medicine and/or clinical neurophysiology. Faculty appointment at Case Western Reserve University will be at any level and commensurate with experience and credentials. Qualifications for Instructor include an MD degree, board certification in Neurology and completion of an accredited neuromuscular or clinical neurophysiology fellowship. Qualifications for Assistant Professor also include demonstrated excellence in patient care, some publications in refereed journals, promise for clinical or translational research, and teaching excellence. Associate Professor candidates should have established a significant professional reputation in patient care, in clinical or translational research through publications in refereed journals or research funding, in teaching excellence or in national service related to Neurology or neuromuscular disorders. Professor candidates should have a distinguished international reputation with a significant record of grants and publications in refereed journals, national service and teaching excellence. University Hospitals Case Medical Center is a national leader in the diagnosis and treatment of autonomic disorders for more than two decades and wishes to further enhance the dedicated autonomic program for adults and children. The autonomic program includes three well equipped laboratories in Northeast Ohio and a dedicated thermoregulatory testing facility. The program is part of the Neuromuscular Center, a nationally recognized center with seven faculty with several EMG laboratories and dedicated muscle disease and ALS programs. In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, member of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-to-case basis. Interested applicants should send a curriculum vitae, three reference letters and contact: Dr. Anthony J. Furlan Chairman, Department of Neurology University Hospitals Case Medical Center 11100 Euclid Avenue (HAN 5040) Cleveland, OH 44106 Email: Anthony.furlan